CAS: 99-40-1; 2-Chloro-1-(3,4-Dihydroxyphenyl)Ethanone

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3,4-二羟基苯乙酮置于n-氯代丁二酰亚胺,对甲苯磺酸体系中,化学反应生成 3,4-二羟基-2'-氯苯乙酮
参考文献:级联三硫自由基(s 3 •-)加成/电子脱甲苯磺酸合成1,2,3-噻二唑和异噻唑
标题:级联三硫自由基(s 3 •-)加成/电子脱甲苯磺酸合成1,2,3-噻二唑和异噻唑
摘要:已经开发了三硫自由基阴离子(s 3 •-)与原位形成的偶氮烯烃和α,β-过饱和的n-磺酰亚胺类化合物介导的反应,用于构建1,2,3-噻二唑和异噻唑.s 3 •-是由dmf中的硫化钾原位反应生成的.这两种方法提供了一种新的,安全的和简单的方法来以高收率构建4-取代的1,2,3-噻二唑,5-取代的1,2,3-噻二唑和异噻唑.反应包括在温和条件下通过s 3 •加成形成新的c-s和n-s键和电子脱甲苯基化反应.
DOI:10.1021/acs.Joc.8B01450

专利信息

专利号:WO-2025058704-A1
优先权日:2023-09-15
标 题:Process for the preparation of epinephrine and norepinephrine
发明人：YUE TAI-YUEN; SAHANI RAJKUMAR; JAYARAMAN ARAVINDAN; DONSBACH KAI; SENANAYAKE CHRIS; QU BO; SIRASANI GOPAL; MANGUNURU HARI; JANGANATI VENUMADHAV; GANGU ARAVIND; TERRAB LEILA; KALIKINIDI NAGESWARA
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:A method of preparing epinephrine or norepinephrine is provided. The method includes reacting a starting material comprising 2-chloro-l-(3,4-dihydroxyphenyl)ethan-l- one with an amine nucleophile RNH2 (R=H for the synthesis of epinephrine or Me for the synthesis of norepinephrine) under conditions suitable for nucleophilic substitution of the starting material to form a substituted starting material and reacting the substituted starting material with a tethered ligand transition metal catalyst under conditions suitable for transfer¬ hydrogenation to produce epinephrine or norepinephrine.

专利号:US-8513395-B2
优先权日:2005-06-15
标题:Method for the synthesis of anthocyanins
发明人：BAKSTAD EINAR
权利人:BAKSTAD EINAR; BIOSYNTH AS
摘要:The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilize a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.

专利号:WO-2016038422-A1
优先权日:2014-09-11
标题:Process for the preparation of optically enriched adrenaline
发明人：PIACENZA GUY; QUERON EMMANUELLE
权利人:ROUVER INVEST S À R L
摘要:A process for the production of (-)-adrenaline and (-)-adrenaline-L-tartrate is provided. The process provides for a new, efficient and commercially feasible process for the optical resolution of racemic adrenaline. In one aspect, a one pot process for the synthesis of (-)-adrenaline is provided. The process provides a simple and less expensive 5 process that can be used to prepare commercial scale batches of (-)-adrenaline and (-)-adrenaline-L-tartrate of API quality. The process avoids the use of expensive and unpredictable chiral catalysts.

专利号:WO-2013008247-A1
优先权日:2011-07-13
标题:Process for preparation of (dl) -norepinephrine acid addition salt, a key intermediate of (r) - (-) - norepinephrine
发明人：DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; KAWLE GANESH RAMACHANDRA
权利人:NEON LAB LTD; DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; KAWLE GANESH RAMACHANDRA
摘要:The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also discloses a novel intermediate formed in the process and its synthesis.

专利号:US-2009111975-A1
优先权日:2005-06-15
标 题 :Method for the synthesis of anthocyanins

专利号:US-5047592-A
优先权日:1989-08-21
标题 :Selective hydrogenolysis process
发明人：CARPENTER JOEL F
权利人:ETHYL CORP
摘要:A relatively simple, economical process for the synthesis of epinine and related compounds is described. The process involves subjecting adrenalone, epinephrine or their respective congeners to selective hydrogenolysis using hydrogen and a metal hydrogenolysis catalyst such as palladium, platinum, rhodium or nickel. Preferably the reaction is conducted in a non-oxidizing acidic liquid reaction medium, such as in aqueous hydrochloric acid.