CAS: 97480-60-9; 1-(3,5-Dimethylphenyl)Thiourea

该化合物是一种硫尿素衍生物,其特点是在苯环的3和5个位置存在两个甲基组,这种结构改变增强了其稳定性和回活动性,使其成为有机合成中有价值的中间体.该化合物对于生产三环化合物和作为协调化学的离子体和离子体特别有用.其电子捐赠型甲基组改善了有机溶剂的溶解性,便利了其在各种反应条件下的使用.此外,3,5-二甲基苯基尿拉由于能够作为生物活性分子的建筑块,在农用化学和制药研究中表现出潜在的应用作用.建议谨慎处理,因为其与硫素有关的毒性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号108-69-0 3,5-二甲基苯胺 | CAS号117174-79-5 N-[(3,5-Dimethy... | CAS号73351-87-8 2-氨基-5,7-二甲基苯并噻唑

合成工艺路线路线简述

  • 117174-79-5 = 97480-60-9
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol; 2 H,Rt
    标题:Preparation Of Coumarin Thiazolyl Derivatives And Methods Of Use In Treating Hyperproliferative Diseases
    参考文献:World Intellectual Property Organization]

    85518-76-9 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Solvents: Water
    标题:Multicomponent One-Pot Synthesis Of Substituted 4H-Pyrimido[2,1-B][1,3]Benzothiazole Curcumin Derivatives And Their Antimicrobial Evaluation
    作者:Agarwal,Shikha; Agarwal,Dinesh Kr.; Gandhi,Divyani; Goyal,Kshamta; Goyal,Pradeep
    参考文献:Letters In Organic Chemistry 日期:2018 卷标:15(10) 页码:863-869]

    85518-76-9 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Reflux; Reflux -> Rt1.2 4 H,Reflux
    标题:Synthesis And In Vitro Antimicrobial Evaluation Of Benzothiazole Incorporated Thiazolidin-4-Ones Derivatives
    作者:Agarwal,Shikha; Agarwal,Dinesh Kumar; Gautam,Naveen; Agarwal,Kshamta; Gautam,Dinesh Chandra
    参考文献:Journal Of The Korean Chemical Society 日期:2014 卷标:58(1) 页码:33-38]

    108-69-0 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Benzoyl Chloride Solvents: Acetone
    标题:New Antiarrhythmic Agents. Piperazine Guanidine Derivatives
    作者:Pascal,Jean Claude; Pinhas,Henri; Laure,Francette; Dumez,Daniele; Poizot,Alain
    参考文献:European Journal Of Medicinal Chemistry 日期:1990 卷标:25(1) 页码:81-5]

    108-69-0 + 1762-95-4 = 97480-60-9 [标题:Reaction Conditions
    标题:Azolopyrimidinones
    参考文献:Federal Republic Of Germany]

    = 97480-60-9 [标题:Reaction Conditions
    标题:Synthesis And Biological Evaluation Of Alkyl,Alkoxy,Alkylthio,Or Amino-Substituted 2,3-Dihydro-1,5-Benzothiazepin-4(5H)-Ones
    作者:Inoue,Hirozumi; Konda,Mikihiko; Hashiyama,Tomiki; Otsuka,Hisao; Watanabe,Akishige; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1997 卷标:45(6) 页码:1008-1026]

    = 97480-60-9 [标题:Reaction Conditions
    标题:Thiazolyl(And Triazoyl)Aminopropenenitriles
    参考文献:Australia]

    108-69-0 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 15 Min,Rt1.2 Rt; 15 H,96 °C; 96 °C -> 25 °C; Overnight,20 - 25 °C
    标题:A Process For The Preparation Of The Compound N-(3,5-Dimethylphenyl)-N'-(2-Trifluoromethylphenyl) Guanidine
    参考文献:Argentina]

    117174-79-5 = 97480-60-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:Improved Procedures For The Preparation Of Cycloalkyl-,And Arylalkyl-,And Arylthioureas
    作者:Rasmussen,C. R.; Villani,F. J. Jr.; Weaner,L. E.; Reynolds,B. E.; Hood,A. R.; Et Al
    参考文献:Synthesis 日期:1988 卷标:(6) 页码:456-9]

    108-69-0 = 97480-60-9
    反应条件:1.1 Solvents: 1,4-Dioxane,Water; 1 - 2 H,Rt1.2 Reagents: Potassium Carbonate; 30 Min,Rt1.3 Reagents: Ammonia Solvents: Water; 50 °C
    标题:Synthesis Of Combinatorial Libraries Of 3-Substituted 2-Methyl-4-Thioxo-3,4,5,6-Tetrahydro-2H-2,6-Methano-1,3,5-Benzoxadiazocines And Their 4-Oxo Analogs In The Biginelli Reaction
    作者:Kovalenko,S. S.; Zaremba,O. V.; Borisova,T. A.; Nikitchenko,V. M.; Kovalenko,S. M.; Et Al
    参考文献:Zhurnal Organichnoi Ta Farmatsevtichnoi Khimii 日期:2008 卷标:6(4) 页码:38-45]

    117174-79-5 = 97480-60-9
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol; 2 H,Rt
    标题:Coumarin Derivatives And Methods Of Use In Treating Cystic Fibrosis,Chronic Obstructive Pulmonary Disease,And Misfolded Protein Disorders
    参考文献:World Intellectual Property Organization]

    108-69-0 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,100 °C
    标题:4-Pyridylanilinothiazoles That Selectively Target Von Hippel-Lindau Deficient Renal Cell Carcinoma Cells By Inducing Autophagic Cell Death
    作者:Hay,Michael P.; Turcotte,Sandra; Flanagan,Jack U.; Bonnet,Muriel; Chan,Denise A.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2010 卷标:53(2) 页码:787-797]

    108-69-0 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,100 °C
    标题:Preparation Of Pyridinyl-Substituted 1,3-Thiazol-2-Amine Derivatives Useful For The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    117174-79-5 = 97480-60-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 1 H,85 °C
    标题:Synthesis And Biological Evaluation Of 3-Amino-1,2,4-Triazole Derivatives As Potential Anticancer Compounds
    作者:Grytsai,Oleksandr; Valiashko,Oksana; Penco-Campillo,Manon; Dufies,Maeva; Hagege,Anais; Et Al
    参考文献:Bioorganic Chemistry 日期:2020 卷标:104]

    108-69-0 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 30 - 40 Min,Reflux; Cooled1.2 4 - 5 H,Reflux
    标题:Design,Synthesis And Antimicrobial Study Of Novel 1-(1,3-Benzothiazol-2-Yl)-3-Chloro-4H-Spiro[azetidine-2,3'-Indole]-2',4(1'H)-Diones Through Ketene-Imine Cycloaddition Reaction
    作者:Gandhi,Divyani; Sethiya,Ayushi; Agarwal,Dinesh Kr.; Prajapat,Prakash; Agarwal,Shikha
    参考文献:Letters In Organic Chemistry 日期:2020 卷标:17(2) 页码:141-148]

    108-69-0 + 1762-95-4 = 97480-60-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Reflux; Reflux -> Rt1.2 4 H,Reflux
    标题:Synthesis,Characterization And Evaluation Of Antimicrobial Activity Of Novel Hybrid Moietiesbenzothiazoles And Azetidinones
    作者:Agarwal,Shikha; Agarwal,Dinesh K.; Garg,Ankita
    参考文献:Chemistry & Biology Interface 日期:2016 卷标:6(2) 页码:99-108]

    = 97480-60-9 [标题:Reaction Conditions
    标题:Preparation Of N-Substituted 2-Chloroacetamides As Small Molecule Modulators Of Ferroptosis
    参考文献:World Intellectual Property Organization]

    = 97480-60-9 [标题:Reaction Conditions
    标题:Coumarin Derivatives And Methods Of Use In Treating Hyperproliferative Diseases
    参考文献:United States
📜N-(3,5-Dimethylphenylcarbamothioyl)Benzamide置于sodium Hydroxide体系中,化学反应 0.33H,反应生成 3,5-二甲基苯基硫脲
参考文献:Effect Of N-1 Arylation Of Monastrol On Kinesin Eg5 Inhibition In Glioma Cell Lines
标题:Effect Of N-1 Arylation Of Monastrol On Kinesin Eg5 Inhibition In Glioma Cell Lines
摘要:为了发现更有效的eg5配体,设计并合成了一种源自单胞杆菌的二氢嘧啶-2-硫酮n-1芳基取代物的原创和专注的图书馆.
DOI:10.1039/c8Md00095F

海关参考信息

专利信息


专利号:CN-107954908-A
优先权日:2017-12-10
标题:A kind of method that phenylthiourea catalyzes the synthesis of diaryl sulfide in aqueous phase under microwave radiation

专利号:US-4223031-A
优先权日:1978-05-05
标题 :Azolopyrimidinones
发明人：COVINGTON ROBERT R; TEMPLE JR DAVIS L; YEVICH JOSEPH P
权利人:MEAD JOHNSON & CO
摘要:6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxy-methylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.

专利号:US-4491587-A
优先权日:1978-05-05
标 题 :Tetrazole derivatives
发明人：COVINGTON ROBERT R; TEMPLE JR DAVIS L; YEVICH JOSEPH P
权利人:MEAD JOHNSON & CO
摘要:6-(1_H-Tetrazol-5-yl)thiazolo[3,2-a]pyrimidin-5-ones, 3-(1_H-tetrazol-5-yl)-4_H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo- pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxymethylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.

专利号:CN-107235916-A
优先权日:2016-12-31
标题:A kind of licochalcone A thiouracil derivative with antitumor activity and its synthesis method

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参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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