CAS: 926280-83-3; Potassium (2-((Tert-Butoxycarbonyl)Amino)Ethyl)Trifluoroborate

相似化合物

1314538-55-0 122234-46-2 2044523-70-6

📜N-Boc-乙烯基胺置于聚合甲醛,Potassium Hydrogen Bifluoride体系中,用 四氢呋喃,水,丙酮 作为反应溶剂,化学反应 4.0H,以60%的收率获得产物n-Boc-氨基乙基三氟硼酸钾
参考文献:Scope Of The Suzuki−miyaura Aminoethylation Reaction Using Organotrifluoroborates
标题:Scope Of The Suzuki−miyaura Aminoethylation Reaction Using Organotrifluoroborates
摘要:Potassium Beta-Aminoethyltrifluoroborates Were Prepared In Good Yields Via Hydroboration Of The Corre-Sponding Enecarbamates Using The Snieckus Hydroborating Reagent. A Wide Variety Of Phenethylamines Containing A Potentially Free Primary Amine After Appropriate Deprotection Have Been Successfully Prepared In Good Yield Using These Organotrifluoroborates As Partners In Suzuki-Miyaura Coupling With Aryl Bromides,Iodides,And Triflates.
DOI:10.1021/jo7015955

专利信息

专利号:US-10227344-B2
优先权日:2016-06-24
标题 :CK2 inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; TAO XUELIANG; BRIN ELENA
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n nFor Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

专利号:WO-2024159288-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting amides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting amides. More specifically, the present invention relates to amides comprising formula (I): (Ia) (Ib), in which the substituents R1 to R27 are selected independently of the groups defined in the description, as well as to processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.