- 相似结构搜索
- InChIKey: DDLVWJKPGCPJKJ-UHFFFAOYSA-N
- InChI=1S/C5H10N2O7P2.3H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);3*1H2
- 计算化学: 氢键受体数11.0氢键供体数8.0可旋转键数4.0
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1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid zoledronic acid monohydrate imidazol-1-ylacetic acid 专利信息
专利号:US-8952172-B2
优先权日:2005-07-28
标 题 :Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it
发明人:LABRIOLA RAFAEL ALBERTO; TOMBARI DORA GRACIELA; VECHHIOLI ADRIANA
权利人:LABRIOLA RAFAEL ALBERTO; TOMBARI DORA GRACIELA; VECHHIOLI ADRIANA; GADOR SA
摘要:A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.