CAS: 86847-59-8; 2,2-Dimethyl-N-Pyridin-2-Yl-Propionamide

该化合物是一种专门的有机化合物,其特点是附在环上的pivalamido组. 这种结构具有独特的消毒和电子特性,在合成化学中具有价值,特别是作为催化剂反应的一种离子体或中间体. 异丁基组增强了稳定性和影响反应性,在选择性转变中提供了优势. 它的强健性允许在多种条件下使用,包括高温或有强力基础的情况下使用. 化合物的模块设计还有利于进一步功能化,使得药物,农用化学或材料科学中能够有针对性地应用. 它的一贯纯度和定义明确的再活动特征使得它成为精确合成的可靠选择.

英文名称2,2-Dimethyl-N-Pyridin-2-Yl-Propionamide
中文名称2-特戊酰胺基吡啶
IUPAC名称N-(pyridin-2-yl)pivalamide
其它别名N-(2-吡啶基)三甲基乙酰胺; 2特戊酰氨基吡啶; 2,2-Dimethyl-N-Pyridin-2-Yl-Propionamide
CAS编号86847-59-8
MFCD编号:MFCD00460277
EINECS号:626-758-8
分子式:C10H14N2O
分子量:178.23
产品CID: 1871738
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: CGSPVYCZBDFPHJ-UHFFFAOYSA-N
InChI=1S/C10H14N2O/c1-10(2,3)9(13)12-8-6-4-5-7-11-8/h4-7H,1-3H3,(H,11,12,13)…
计算化学: 氢键受体数2.0氢键供体数1可旋转键数1

相似化合物

101630-94-8 86847-79-2 86847-78-1

物理性质

熔点71-75°C
沸点349.3±15.0 °C at 760 mmHg
闪点165.1±20.4 °C
密度1.1±0.1 g/cm3
pKa:13.82±0.70(预测)
PSA:41.99
LogP:2.0662
折射率1.548
蒸汽压0.0±0.8 mmHg at 25°C
溶解性Dichloromethane, Ethyl Acetate, Methanol
外观形态白色固体
储存条件密封, 常温干燥保存

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2
皮肤致敏类别1
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H319 |造成严重眼刺激.
H317 |可能引起皮肤过敏反应.
防范说明P233-P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P363-P405-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn,Xi
安全声明26-36
危险类别码22-36/37
WGK Germany3

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

75-98-9 + 14150-95-9 = 86847-59-8
反应条件:1.1 Reagents: Diisopropylethylamine,O-(7-Azabenzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Hexafluorophosphate Solvents: Dimethylformamide; 1 - 2 H,Rt1.2 Reagents: Diboronic Acid; 10 Min,Rt1.3 Solvents: Water; Rt
标题:Rapid And Selective In Situ Reduction Of Pyridine-N-Oxides With Tetrahydroxydiboron
作者:Londregan,Allyn T.; Et Al
参考文献:Synlett 日期:2013 卷标:24(20) 页码:2695-2700]

75-98-9 = 86847-59-8
反应条件:1.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C1.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C1.3 Rt; 1.5 H,Rt1.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

24331-71-3 = 86847-59-8
反应条件:1.1 Catalysts: Silica,Sulfuric Acid; 10 H,70 °C
标题:Sulphuric Acid Immobilized On Silica Gel (H2So4-Sio2) As An Eco-Friendly Catalyst For Transamidation
作者:Rasheed,Sk.; Et Al
参考文献:Rsc Advances 日期:2015 卷标:5(14) 页码:10567-10574]

171520-81-3 = 86847-59-8
反应条件:1.1 Reagents: Cupric Acetate,Potassium Carbonate Solvents: O-Xylene; 24 H,140 °C
标题:Copper- Or Nickel-Enabled Oxidative Cross-Coupling Of Unreactive C(Sp3)-H Bonds With Azole C(Sp2)-H Bonds: Rapid Access To β-Azolyl Propanoic Acid Derivatives
作者:Tan,Guangying; Et Al
参考文献:Organic Letters 日期:2017 卷标:19(18) 页码:4830-4833]

14150-95-9 = 86847-59-8
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 8 H,Rt
标题:Palladium-Catalyzed Selective β-Arylation Of Aliphatic Amides Using A Removable N,O-Bidentate Auxiliary
作者:Zhang,Shou-Kun; Et Al
参考文献:Organometallics 日期:2015 卷标:34(17) 页码:4331-4339]

5123-13-7 + 13606-95-6 = 86847-59-8
反应条件:1.1 Catalysts: Triruthenium Dodecacarbonyl Solvents: Isopropanol; 24 H,140 °C2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

2266573-81-1 = 86847-59-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Rt2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

= 86847-59-8
反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; Overnight,Rt
标题:Rhodium(Iii)-Catalyzed Oxidative Olefination Of Pyridines And Quinolines: Multigram-Scale Synthesis Of Naphthyridinones
作者:Zhou,Jun; Et Al
参考文献:Organic Letters 日期:2013 卷标:15(13) 页码:3460-3463]

75-98-9 = 86847-59-8
反应条件:1.1 Reagents: Diisopropylethylamine,2-Pyridinamine,1-Oxide,Bop Reagent Solvents: Dimethylformamide; 1 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water1.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 15 H,30 Psi,Rt
标题:An Improved Amide Coupling Procedure For The Synthesis Of N-(Pyridin-2-Yl)Amides
作者:Londregan,Allyn T.; Et Al
参考文献:Tetrahedron Letters 日期:2009 卷标:50(17) 页码:1986-1988]

57785-86-1 + 754-10-9 = 86847-59-8
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: 1,1-Bis(Diphenylphosphino)Ferrocene,Bis(Dibenzylideneacetone)Palladium Solvents: 1,4-Dioxane; 16 H,100 °C
标题:Pd-Catalyzed C-N Bond Formation With Heteroaromatic Tosylates
作者:Mantel,Mette L. H.; Et Al
参考文献:Chemistry - A European Journal 日期:2010 卷标:16(18) 页码:5437-5442]

153766-81-5 + 13606-95-6 = 86847-59-8
反应条件:1.1 Catalysts: Triruthenium Dodecacarbonyl Solvents: Isopropanol; 24 H,140 °C2.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.2 Rt; 1.5 H,Rt2.3 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

13606-95-6 + 24388-23-6 = 86847-59-8
反应条件:1.1 Catalysts: Triruthenium Dodecacarbonyl Solvents: Isopropanol; 24 H,140 °C2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

4406-77-3 + 13606-95-6 = 86847-59-8
反应条件:1.1 Catalysts: Triruthenium Dodecacarbonyl Solvents: Isopropanol; 24 H,140 °C2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

5123-13-7 + 13606-95-6 = 86847-59-8
反应条件:1.1 Catalysts: Triruthenium Dodecacarbonyl Solvents: Isopropanol; 24 H,140 °C2.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.2 Rt; 1.5 H,Rt2.3 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

13606-95-6 = 86847-59-8
反应条件:1.1 Reagents: 2-Phenyl-1,3,2-Benzodioxaborole Catalysts: Triruthenium Dodecacarbonyl Solvents: Isopropanol; 24 H,140 °C2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

2266573-89-9 = 86847-59-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Rt2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

2266573-98-0 = 86847-59-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,80 °C2.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C2.3 Rt; 1.5 H,Rt2.4 Solvents: Water; Rt
标题:Ruthenium-Catalyzed Reductive Arylation Of N-(2-Pyridinyl)Amides With Isopropanol And Arylboronate Esters
作者:Ronson,Thomas O.; Et Al
参考文献:Angewandte Chemie 日期:2019 卷标:58(2) 页码:482-487]

= 86847-59-8
反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C; 1 H,0 °C -> Rt
标题:Regioselective Ketone α-Alkylation With Simple Olefins Via Dual Activation
作者:Mo,Fanyang; Et Al
参考文献:Science (Washington 日期:2014 卷标:345(6192) 页码:68-72

Methyl 4-(Pyridin-2-Ylcarbamoyl)Benzoate置于盐酸,十二羰基三钌,三乙胺,异丙醇体系中,用四氢呋喃,水作为反应溶剂,化学反应 41.5H,反应生成 2-特戊酰胺基吡啶
参考文献:钌催化的n-(2-吡啶基)酰胺与异丙醇和芳基硼酸酯的还原化
标题:钌催化的n-(2-吡啶基)酰胺与异丙醇和芳基硼酸酯的还原化
摘要:描述了一种新的酰胺与稳定反应物的三组分还原芳基化反应(iproh和芳基硼酸酯),利用2-吡啶基(py)导向基团.n-Py-酰胺底物可以很容易地由羧酸和pynh 2制备,所得的n-Py-1-芳基烷胺反应产物很容易通过用hcl取代hn-Py基团而转化为相应的氯化物.1-芳基-1-氯代烷烃产品可进行取代和交叉偶联反应.因此,获得了将羧酸转化成各种官能团的通用方案.py‐nh 2副产物可以回收利用.
DOI:10.1002/anie.201810947

海关参考信息

2912110000-甲醛
2912120000-乙醛
2933310010-吡啶
2924199090-其他无环酰胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2006183758-A1
优先权日:2005-02-17
标题:Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
发明人：BEARD CHARLES D; LEE VING J; WHITTLE C E
权利人:CB RES AND DEV INC
摘要:Methods of synthesis of intermediates that are useful as bioisosteres of the indole, benzofuran and benzothiophene scaffold are disclosed.

专利号:WO-2008022467-A1
优先权日:2006-08-25
标题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).

专利号:US-7361671-B2
优先权日:2001-11-15
标题 :Substituted heteroarylalkanoic acids
发明人：VAN ZANDT MICHAEL C; GERACI LEO
权利人:INST PHARMACEUTICAL DISCOVERY
摘要:Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)Râ€², where D, A, and Râ€² are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

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网址: http://www.pyridinechem.com
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合成参考文献

摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2017) 1, 260.
摘要:Walker, J. C. L., Science of Synthesis: Knowledge Updates, (2024) 3, 224.

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CAS: 86847-59-8; 2,2-Dimethyl-N-Pyridin-2-Yl-Propionamide

相似化合物

物理性质

MSDS等安全信息

欧盟法规

上下游产品

合成工艺路线路线简述

海关参考信息

专利信息

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