CAS: 77359-11-6; 3-((4-Nitrobenzyl)Oxy)-3-Oxopropanoic Acid

上下游产品

CAS号67245-85-6 丙二酸双(4-硝基苯甲基)酯 | CAS号619-73-8 对硝基苯甲醇 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号28509-24-2 tert.-butyl-met...

对硝基苯甲醇置于丙二酸,对甲苯磺酸体系中,用 甲苯 作为反应溶剂,以59%的收率获得产物丙二酸单对硝基苄酯
参考文献:Crystal Modification Of Magnesium Salt Of Mono-P-Nitrobenzyl Malonate
标题:Crystal Modification Of Magnesium Salt Of Mono-P-Nitrobenzyl Malonate
摘要:本发明提供了一种单p-硝基苯甲酸酯镁盐的晶体改性(以下简称为"β型晶体"),其特征在于其x射线衍射图谱在cu-Kα线下具有强的衍射角度峰值(2θ)[°] 4.5,8.9和13.3,并提供了一种制备单p-硝基苯甲酸酯镁盐β型晶体改性的方法,包括将水溶性镁盐与单p-硝基苯甲酸酯的碱金属盐或铵盐反应的步骤.该方法便于生产纯度高于已知α型晶体改性的β型晶体改性.β型晶体是制药起始原料的非常有用的中间体.

专利信息

专利号:US-4282148-A
优先权日:1980-01-14
标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4414155-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4360684-A
优先权日:1981-04-08
标 题 :Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid
发明人：CVETOVICH RAYMOND J; MELILLO DAVID G; RYAN KENNETH M; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for preparing (2S)-tetrahydro-2 alpha -methyl-6-oxo-4 beta -amino-2H-pyran-3 alpha -carboxylic acid (I) which is useful in the synthesis of thienamycin. The process proceeds via a stereospecific reduction of the 2-acetyl-3-(R)- alpha -methylbenzylamino-2-pentenedioic acid diester (II). I II wherein R is, alpha -methylbenzyl, and R1 is lower alkyl having 1-6 carbon atoms or arylalkyl such as benzyl.

专利号:US-5134231-A
优先权日:1985-12-28
标题 :3(1-hydoxyethyl)azetidinone compounds and their production
发明人：SUNAGAWA MAKOTO; NOZAKI YOSHIHITO; SASAKI AKIRA; MATSUMURA HARUKI
权利人:SUMITOMO PHARMA
摘要:An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R 1 is a hydrogen atom or a protecting group for carboxyl, R 2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl group of the formula: ##STR2## (wherein R 3 and R 4 are each a hydrogen atom, a lower alkyl group or an aryl group), a beta-hydroxyethyl group in which the hydroxyl group is optionally protected, a formylmethyl group in which the formyl group is optionally protected, a carboxymethyl group in which the carboxyl group is protected or a 2-furylmethyl group and X is an optionally protected carboxyl group, a hydroxymethyl group in which the hydroxyl group is optionally protected or a substituted mercaptomethyl group of the formula: n n --CH.sub.2 SR.sub.5 n n (wherein R 5 is an aryl group or an ar(lower)alkyl group), which is a useful intermediate in the synthesis of 1-alkylcarbapenem compounds.

专利号:US-4996314-A
优先权日:1986-03-11
标题 :6-(disubstituted amino)carbapenem compounds
发明人：YOSHIOKA TAKEO; CHIDA NORITAKA; WATANABE AZUMA; FUKAGAWA YASUO; ISHIKURA TOMOYUKI
权利人:SANRAKU INC
摘要:A compound represented by the formula ##STR1## wherein R 1 represents a lower alkyl group or a lower haloalkyl group; R 2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR 4 or --SO 2 R 5 in which R 4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R 5 represents an alkyl group or a substituted or unsubstituted aryl group; and R 3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. n The compounds of the formula ##STR2## wherein R 1 and R 2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

专利号:WO-2011072287-A2
优先权日:2009-12-11
标题 :Method for late introduction of the (8r)-hydroxyl group in carbapenem beta-lactam antibiotic synthesis