CAS: 7291-22-7; Pyridine D5

上下游产品

CAS号110-86-1 吡啶 | CAS号100-70-9 2-氰基吡啶 | CAS号100-54-9 3-氰基吡啶 | CAS号100-48-1 4-氰基吡啶 | CAS号139-66-2 苯硫醚 | CAS号109-99-9 四氢呋喃 | CAS号676-49-3 甲烷-d1 | CAS号1291078-54-0 ethyl (E)-3-(py... | CAS号59607-99-7 (E)-3-(吡啶-3-基)丙烯酸乙酯 | CAS号4423-10-3 吡啶 4-(4-甲基苯基)- | CAS号4467-06-5 2-(对甲苯基)吡啶 | CAS号4423-09-0 3-(4-甲基苯基)吡啶

吡啶置于(1,5-Cyclooctadiene)(Methoxy)Iridium(I) Dimer,氘体系中,用 四氢呋喃 作为反应溶剂,55.0 °C,100.0 Kpa 条件下,反应 22.0H,反应生成 氘代吡啶
参考文献:药物的多位点氢同位素标记
标题:药物的多位点氢同位素标记
摘要:摘要放射性标记是药物发现和开发的基础,因为它是临床前 Adme 研究和后期人体临床试验的强制性要求.本文提出了一种通用,有效且易于实施的方法,使用市售且空气稳定的铱预催化剂 [ir(Cod)(Ome)] 来多位点掺入氘和氚原子.2被描述.使用这种方法可以标记大量与药物相关的子结构,包括吡啶,吡嗪,吲哚,咔唑,苯胺,恶唑/噻唑,噻吩以及富电子苯基.各种复杂药物的标记突出了该反应的高官能团耐受性,特别是含有卤素或硫原子和腈基团.多位点氢同位素掺入可以通过原位形成互补的催化活性物质来解释:单金属铱络合物和铱纳米颗粒.
DOI:10.1002/ange.202008519

专利信息

专利号:US-5856465-A
优先权日:1996-05-24
标 题:Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
发明人：STEC WOJCIECH JACEK; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:EP-0850248-B1
优先权日:1995-09-01
标 题 :Compositions and methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:US-6262251-B1
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

专利号:WO-9847910-A1
优先权日:1997-04-21
标题:Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.