CAS: 71648-45-8; 2'-Chloro-5'-(Trifluoromethyl)Acetophenone

该化合物是一种多用途芳香酮衍生物,其特点是在丙酮骨干上存在氯和三氟甲基替代物,其独特的结构具有很强的电子拖车特性,使其成为有机合成的宝贵中间体,特别是在制药,农用化学品和特殊化学品的制备方面;三氟甲基混合物可增强代谢稳定性和亲脂性,而氯替代成分可提供再活动性,以进一步实现功能化;该化合物通常用于交叉反应,核分裂哲学替代以及作为七环框架的建筑块;其高纯度和一贯性能使其适合于需要精确结构修改的研究和工业应用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:WO-2010001220-A1
    优先权日:2008-07-01
    标 题 :New 1,2,4-triazine derivatives and biological applications thereof
    发明人：DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA
    权利人:MUTABILIS SA; DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA
    摘要:The invention relates to new 1,2,4-triazine derivatives of formula (I): wherein A, B, R2 and Y are defined in the application, their preparation and intermediates, their use as drugs and pharmaceutical compositions and associations containing them. The compounds of formula (I) are capable of inhibiting bacterial heptose synthesis.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Copper(I) Iodide Catalyzed Synthesis Of Quinolinones Via Cascade Reactions Of 2-Halobenzocarbonyls With 2-Arylacetamides
    作者:Ke Ding,Liangbing Fu,Xiaoli Huang,Deping Wang,Pinghua Zhao |发布日期:2011.5
    摘要:An Efficient Copper-Catalyzed Method For The Synthesis Of Quinolinones, Pyridinones, And Heteroannulated Pyridinones Via Cascade Reactions Of Substituted 2-Iodo-, 2-Bromo-, And 2-Chlorobenzocarbonyls With 2-Arylacetamides Is Reported. The Protocol Works Well For The Reaction Of Most Of The 2-Iodo-, 2-Bromo- And 2-Chlorobenzocarbonyls With 2-Arylacetamides. Copper Iodide - Diamines - Cascade Reactions

    合成参考文献


    参考文献:10.1055/s-0030-1259983
    摘要:Ding K, Fu L, Huang X, Wang D, Zhao P. Copper(I) Iodide Catalyzed Synthesis of Quinolinones via Cascade Reactions of 2-Halobenzocarbonyls with 2-Arylacetamides. Synthesis. 2011 Apr 01;2011(10):1547–54. doi: 10.1055/s-0030-1259983.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知