CAS: 68206-45-1; 3-Nitro-2-Pyridinesulfenylchloride

相似化合物

38240-29-8 130156-01-3 68118-07-0

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CAS号69212-31-3 2-苄硫基-3-硝基吡啶 | CAS号5470-18-8 2-氯-3-硝基吡啶 | CAS号153815-22-6 2-[(4-methoxyph... | CAS号76880-29-0 (R)-2-((叔丁氧基羰基)...

📜4-Methoxybenzyl 3-Nitro-2-Pyridyl Sulfide置于磺酰氯体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.33H,反应生成 3-硝基-2-吡啶硫酰氯
参考文献:A New Method For The Preparation Of 3-Nitro-2-Pyridinesulfenyl Chloride And One-Pot Syntheses Ofn(α)-Tert-Butoxycarbonyl-S-3-Nitro-2-Pyridinesulfenyl Derivatives Of Cysteine And D-Penicillamine
标题:A New Method For The Preparation Of 3-Nitro-2-Pyridinesulfenyl Chloride And One-Pot Syntheses Ofn(α)-Tert-Butoxycarbonyl-S-3-Nitro-2-Pyridinesulfenyl Derivatives Of Cysteine And D-Penicillamine
摘要:通过 3-硝基-2-吡啶苄基硫化物与硫酰氯的反应制备了 3-硝基-2-吡啶硫酰氯.使用 4-甲氧基苄基 3-硝基-2-吡啶硫化物完成了半胱氨酸和 D-青霉胺的 N (δ)-叔丁氧羰基-S-3-硝基-2-吡啶亚磺酰基衍生物的一锅合成.
DOI:10.1055/s-1994-25394

专利信息

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-2009221568-A1
优先权日:2005-11-04
标题:Synthesis of Inhibitors of FtsZ
发明人：SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
权利人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
摘要:FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2′″-hydroxy-5″-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-7414106-B2
优先权日:2003-06-19
标 题 :Synthesis of peptide α-thioesters
发明人：CAMARERO JULIO A; MITCHELL ALEXANDER R; DE YOREO JAMES J
权利人:L LIVERMORE NAT SECURITY LLC
摘要:Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. When the peptide synthesis has been completed, activation of the linker is achieved by mild oxidation. The oxidation step converts the acyl-hydrazine group into a highly reactive acyl-diazene intermediate which reacts with an α-amino acid alkylthioester (H-AA-SR) to yield the corresponding peptide α-thioester in good yield. A variety of peptide thioesters, cyclic peptides and a fully functional Src homology 3 (SH3) protein domain have been successfully prepared.