CAS: 6519-27-3; Methyl (R)-2-((2R,12Bs,E)-3-Ethylidene-1,2,3,4,6,7,12,12B-Octahydroindolo[2,3-A]Quinolizin-2-yl)-3-Hydroxypropanoate

该化合物是一种化学化合物,属于alkaloids类,是自然产生的有机化合物,大多含有基本的氮原子;Alkaloids因具有多种药理效应而闻名,而且往往来自植物来源;Isositsirikine的特征是其特定的分子结构,有助于其生物活动;尽管其特性的详细信息可能有限,但该类别中的化合物通常具有一系列影响,包括潜在的治疗用途;Isosisitirkine可能因其与生物系统的互动而受研究,包括对...

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    上下游产品

    4,21-dehydrogeissoschizine hydr°Chloride *-(3α,15α)]-3,4,5,6,14,15,21-heptahydro-15-(methyl acetate)-20-ethylidene-indolo[2,3-a]quinolizine20E-[3S*-(3α,15α)]-3,4,5,6,14,15,21-heptahydro-15-(methyl acetate)-20-ethylidene-indolo[2,3-a]quinolizine (Z)-methyl 2-((2S,12bS,E)-3-ethylidene-1,2,3,4,6,7,12,12b-°Ctahydroindolo[2,3-a]quinolizin-2-yl)-3-hydroxyacrylate

    合成工艺路线路线简述

      📜<(2α,3E,12Bβ)-3-Ethyliden-1,2,3,4,6,7,12,12B-octahydro-4-Oxoindolo<2,3-A>Chinolizin-2-Yl>Essigsaeure-Methylester 反应生成 拉兹马宁碱
      参考文献:Naito,Takeaki;Shinada,Tetsuro;Miyata,Okiko;Ninomiya,Ichiya;Ishida,To+,Heterocycles.,27,(1988) N,C. 1603-1606
      标题:Naito,Takeaki;Shinada,Tetsuro;Miyata,Okiko;Ninomiya,Ichiya;Ishida,To+,Heterocycles.,27,(1988) N,C. 1603-1606

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      专利信息


      专利号:US-11072613-B2
      优先权日:2016-03-02
      标 题:Compositions and methods for making terpenoid indole alkaloids
      发明人：DE LUCA VINCENZO; QU YANG
      权利人:WILLOW BIOSCIENCES INC
      摘要:Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids, including tabersonine and catharanthine are also provided. The provided compounds are useful in the manufacture of chemotherapeutic agents.

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      主要参考文献

      参考标题:Total Syntheses Of Naucleamides A-C And E, Geissoschizine, Geissoschizol, (E)-Isositsirikine, And 16-Epi-(E)-Isositsirikine
      作者:Lei Li,Paruke Aibibula,Qianlan Jia,Yanxing Jia |发布日期:2017.5.19
      摘要:A Divergent Approach For The Enantioselective Total Synthesis Of Eight Monoterpenoid Indole Alkaloids Was Developed. The Approach Allows The First Total Syntheses Of Naucleamides A-C And E In Only 6-8 Steps And Also Enables The Efficient Synthesis Of Geissoschizine, Geissoschizol, (E)-Isositsirikine, And 16-Epi-(E)-Isositsirikine In 10-11 Steps From Commercially Available Crotonic Aldehyde. The Synthesis

      合成参考文献


      参考文献:10.1016/j.tet.2004.03.031
      摘要:Kam T, Choo Y, Komiyama K. Unusual spirocyclic macroline alkaloids, nitrogenous derivatives, and a cytotoxic bisindole from Alstonia. Tetrahedron. 2004 Apr;60(18):3957–66. doi: 10.1016/j.tet.2004.03.031.
      参考文献:10.1016/s0031-9422(97)00513-x
      摘要:Kam T, Sim K. Alkaloids from Kopsia griffithii. Phytochemistry. 1998 Jan;47(1):145–7. doi: 10.1016/s0031-9422(97)00513-x.
      参考文献:10.1016/j.phytochem.2011.08.001
      摘要:Ku WF, Tan SJ, Low YY, Komiyama K, Kam TS. Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba. Phytochemistry. 2011 Dec;72(17):2212–8. doi: 10.1016/j.phytochem.2011.08.001.
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