CAS: 621-79-4; Cinnamamide (Predominantly Trans)

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CAS号591-50-4 碘苯 | CAS号79-06-1 丙烯酰胺 | CAS号59336-59-3 2-Propenal, 3-p... | CAS号98-80-6 苯硼酸 | CAS号140-10-3 肉桂酸 | CAS号108-86-1 溴苯 | CAS号292638-84-7 phenylene-ethylene | CAS号201230-82-2 carbon monoxide | CAS号588-72-7 Benzene, [(1E)-... | CAS号13372-81-1 肉桂醛肟 | CAS号4165-96-2 3-苯基戊二酸 | CAS号20314-83-4 3-phenylprop-2-... | CAS号103-26-4 肉桂酸甲酯 | CAS号122-97-4 3-苯丙醇 | CAS号1885-38-7 肉桂腈 | CAS号645-59-0 苯代丙腈 | CAS号4192-77-2 反式肉桂酸乙酯 | CAS号4360-47-8 3-苯基丙烯腈 | CAS号102-93-2 3-苯基丙酰胺 | CAS号140-10-3 肉桂酸

肉桂醛置于盐酸羟胺体系中,用 乙腈 作为反应溶剂,化学反应 0.06H,以90%的收率获得产物肉桂酰胺
参考文献:氯化硅催化微波辅助醛类高效选择性一锅法合成酰胺
标题:氯化硅催化微波辅助醛类高效选择性一锅法合成酰胺
摘要:酰胺功能在有机和生物化学中普遍存在.酰胺被用作有机合成中的保护基团,因为它们具有在广泛的条件下具有非常好的稳定性的优点.它们作为技术聚合物,药物,农用化学品,肽和蛋白质发挥着重要作用.酰胺是由羧酸与胺反应形成的.其他替代方法包括 Schotten-Baumann 反应,Beckmann 重排,Willgerodt 反应,Ugi 反应,Chapmann 重排,脱氢酰化.文献中存在醛肟向酰胺的转化.我们还进行了酰胺与腈的相互转化,反之亦然.近年来,固相合成已成为有机合成中最重要的工具之一.通过用硅胶处理 Socl2 制备氯化硅(方案 1).由于其在有机溶剂中的不溶性和产生路易斯酸中心的不稳定si-Cl键的存在,以及亲核体接受特性,它可以用于不同的用途.sio2-Cl催化的羰基化合物保护和氨基烷基-2-萘酚的合成是众所周知的反应.氯化硅也用于制备其他硅胶键合试剂.二氧化硅表面的氯化程度通过在 25
DOI:10.5012/bkcs.2012.33.7.2129

专利信息

专利号:US-6794534-B2
优先权日:2000-06-23
标题:Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; MORGAN JOHN P; SCHOLL MATTHIAS; CHOI TAE-LIM
权利人:CALIFORNIA INST OF TECHN
摘要:The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of α-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are each independently an anionic ligand; n L is a neutral electron donor ligand; and, n R, R 1 R 6 , R 7 , R 8 , and R 9 are each independently hydrogen or a substituent selected from the group consisting of C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl.

专利号:US-7816544-B2
优先权日:2004-03-23
标 题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species
发明人：JONES II GUILFORD; GERARD BAUDOUIN; PORCO JR JOHN A
权利人:UNIV BOSTON
摘要:The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.

专利号:US-8951728-B2
优先权日:2004-11-22
标 题:Template directed split and mix synthesis of small molecule libraries
发明人：RASMUSSEN PETER BIRK
权利人:CHEMGENE HOLDING APS
摘要:The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

专利号:US-6573387-B1
优先权日:1997-03-21
标 题 :Synthesis of α,β-substituted amino amides, esters, and acids
发明人：SHARPLESS K BARRY; RUBIN A ERIK
权利人:SCRIPPS RESEARCH INST
摘要:α,β-Unsaturated amides and esters are converted to α,β-substituted amino amides, esters, and acids. An α,βunsaturated amide or ester is first converted to an α,β-hydroxysulfonamide or hydroxycarbamate amide or ester using an osmium-catalyzed aminohydroxylation. The α,β-hydroxysulfonamide or hydroxycarbamate amides or esters is then cyclodehydrated to produce a α,β-N-sulfonyl- or the α,β-N-carbamoylaziridine amide or ester. The ring of aziridine intermediate is then nucleophilically opened in a regioselective manner with a variety of nucleophiles to give the $g(α,β-substituted amino- amides or esters. Preferred nucleophiles include sulfur, oxygen, carbon, and nitrogen nucleophiles.

专利号:WO-2016202721-A1
优先权日:2015-06-16
标 题:Salts of (s)-4-[(r)-6-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-3,6- dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid, salt former and methods for preparing and using the same
发明人：EGLI ANDRé; DIODONE RALPH; WUITSCHIK GEORG
权利人:HOFFMANN LA ROCHE; HOFFMANN LA ROCHE
摘要:The present invention relates to salts of (S)-4-[(R)-6-(2-Chloro-4-fluoro-phenyl)-5- methoxycarbonyl-2-thiazol-2-yl-3,6-dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid and an acid, the synthesis of the acid salts, and their use for the treatment of pathological disorders, particularly hepatitis B (HBV) infection.

专利号:WO-2014012832-A1
优先权日:2012-07-16
标 题:Process for the preparation of 2-(3-n,n-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol and its derivatives
发明人：PICCOLO ORESTE; GIANNINI ELIOS; BIGINI LAURA; GIANOLLI EDOARDO; VIGO DANIELE
权利人:CAMBREX PROFARMACO MILANO S R L
摘要:The invention concerns a process for the preparation of 2-(3-N,N- diisopropylamino-l-phenylpropyl)-4-hydroxymethyl-phenol and its derivatives, particularly the corresponding (R) 4-trityloxymethyl derivative, useful as intermediate form in the synthesis of Fesoterodine and its salts, in particular for the preparation of Fesoterodine fumarate salt.