CAS: 54585-47-6; 4,6-Dimethyl-2-Thioxo-1,2-Dihydropyridine-3-Carbonitrile

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CAS号7357-70-2 2-氰基硫代乙酰胺 | CAS号123-54-6 乙酰丙酮 | CAS号6623-21-8 4,6-二甲基烟腈 | CAS号5875-28-5 Thi°Cyanic acid... | CAS号129224-51-7 2-氰基-2-环亚戊基乙烷硫代酰胺 | CAS号129224-53-9 2-cyano-2-cyclo... | CAS号63913-42-8 (E)-4-morpholin... | CAS号52505-42-7 1-(3-氨基-4,6-二甲基... | CAS号58327-76-7 3-氨基-4,6-二甲基噻吩并... | CAS号41601-44-9 4,6-二甲基-3-氨基吡唑并... | CAS号128918-28-5 3-氨基-4,6-二甲基噻吩[... | CAS号128918-14-9 2-[(3-amino-4,6... | CAS号52505-56-3 Thieno[2,3-b]py... | CAS号14237-71-9 2-氯-3-氰基-4,6-二甲基吡啶 | CAS号72456-86-1 4,6-dimethyl-2-... | CAS号67795-42-0 3-氨基-4,6-二甲基噻吩[... | CAS号835626-21-6 (3-azido-4,6-di...

📜2-氯-3-氰基-4,6-二甲基吡啶置于硫脲体系中,用 乙醇 作为反应溶剂,以83 %的收率获得产物3-氰基-4,6-二甲基-2-硫基吡啶
参考文献:通过砜的配体偶联反应进行 N-杂芳族氟烷基化
标题:通过砜的配体偶联反应进行 N-杂芳族氟烷基化
摘要:通过格氏试剂促进的形式so 2挤出反应,由氟烷基2-氮杂杂芳基砜有效合成氟烷基化n-杂芳烃.该反应通过五配位硫(Vi)中间体的配体偶联进行,并表现出独特的氟效应.
DOI:10.1002/anie.202401091

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-111699248-A
优先权日:2018-01-31
标题:Biocatalysts and methods for the synthesis of mixed disulfide conjugates of thienopyridine compounds

专利号:US-12188069-B2
优先权日:2018-01-31
标 题 :Biocatalyst and methods for synthesizing mixed disulfide conjugates of thienopyridine compounds
发明人：ZHANG HAOMING
权利人:UNIV MICHIGAN REGENTS
摘要:The present invention relates to methods for synthesizing mixed disulfide conjugates of thienopyridine compounds with a genetically engineered variant of cytochrome P450 BM3 or CYP102A1 as a catalyst, and belongs to the field of chemical synthesis.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9056876-B2
优先权日:2011-09-16
标 题:Substituted 1H-pyrazolo[3′,4′,4,5]thieno[2,3-b]pyridin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：CONN JEFFREY P; LINDSLEY CRAIG W; WOOD MICHAEL R; HOPKINS COREY R; SALOVICH JAMES M; MELANCON BRUCE J
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 1H-pyrazolo[3′,4′:4,5]thieno[2,3-b]pyridin-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.