CAS: 33765-68-3; (8R,9S,10R,13S,14S,16S,17S)-16-Ethyl-17-Hydroxy-13-Methyl-2,6,7,8,9,10,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-One
该化合物是一种合成代谢类固醇,产自睾丸酮,其特点是能够促进肌肉生长,提高体能,使其对医疗和运动环境都感兴趣;化学上,它是17-甲基苯甲酮的衍生物,有助于其新陈性质,同时尽量减少其影响和诱因效应;氧苯丙酮通常以口服方式施用,并已知其毒性相对较低,与其他代谢类类相比,其毒性较低;其药理学效应包括蛋白合成增加,氮保留和总体代谢活动,这可以帮助恢复和肌肉发育;然而,与许多代谢类固醇一样,它也可能与一系列副作用有关,包括荷尔蒙失衡和潜在的心血管问题;由于其性能增强能力,Oxendolone经常在竞争性体育中被禁止;与任何此类物质一样,必须考虑治疗益处及其使用的潜在风险.
- 英文名称(8R,9S,10R,13S,14S,16S,17S)-16-Ethyl-17-Hydroxy-13-Methyl-2,6,7,8,9,10,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-One
- 中文名称奥生多龙
- IUPAC名称(8R,9S,10R,13S,14S,16S,17S)-16-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
- 其它别名Estr-4-en-3-one,16b-ethyl-17b-hydroxy- (8CI); 16b-Ethyl-17b-hydroxyestr-4-en-3-one; 16b-Ethyl-19-nortestosterone; Oxendolone
- CAS编号33765-68-3
- MFCD编号:MFCD00864663
- FDA UNII编号:MN4I850D4P
- 分子式:C20H30O2分子量:302.455
- 产品CID: 1334048
- 产品分类原料药 → 激素及调节内分泌功能类药 → 雄激素及同化激素类药
物理性质
- 熔点152-153 °C
- 沸点451.7 °C at 760mmHg
- 闪点192.4 °C
- 密度1.1g/cm3
- PH:D +41° (c = 1.0 in ethanol)
- pKa:15.08±0.60(预测)
- PSA:37.3
- LogP:4.1252
- 折射率1.553
- 蒸汽压4.66E-10 mmHg at 25 °C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用奥生多龙(33765-68-3)的用途:抗雄性激素药物,有抗雄性激素作用.在前列腺直接与雄性激素发生竞争性拮抗,而抑制前列腺及精囊的重量.用于前列腺肥大的治疗.
- 性质描述奥生多龙(33765-68-3)的化学性质:从乙醚结晶,熔点152-153°C.[α]D+41°(C=1.0,乙醇).UV最大吸收(乙醇):240nm(ε15800).对热,湿气及灯光稳定.在日光作用下转化为16α-和17α-异构体.急性毒性LD50大鼠和小鼠(g/kg):＞10口服;5～10肌肉注射和腹腔注射.
上下游产品
CAS号33765-85-4 3-methoxy-16β-e... | CAS号75-65-0 叔丁醇 | CAS号33765-70-7 3-methoxy-16β-e...合成工艺路线路线简述
📜3-Methoxy-16β-Ethyl-1,3,5(10)-Estratrien-17β-Ol 反应生成奥生多龙
参考文献:A Stereoselective Synthesis And Nuclear Magnetic Resonance Spectral Study Of Four Epimeric 17-Hydroxy-16-Ethylestranes.
标题:A Stereoselective Synthesis And Nuclear Magnetic Resonance Spectral Study Of Four Epimeric 17-Hydroxy-16-Ethylestranes.
摘要:从 16α-乙基-16β,17β-二醇单乙酸酯 (2) 开始,立体选择性地制备了四种具有有效抗雄激素活性的差向异构 17-羟基-16-乙基酯-4-En-3-酮 (11).研究了四种差向异构体和其他 16 取代雌烷和雄烷的核磁共振谱,以阐明 16 和 17 位未知构型分配的可能性.耦合常数数据 (J16,17 )和化学位移(13-甲基质子和17-质子)可用于确定16和17位的构型.
Doi:10.1248/cpb.25.1295
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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📌 第三方产品分析报告
主要参考文献
1: Hikichi Y, Yamaoka M, Kusaka M, Hara T. Selective androgen receptor modulator activity of a steroidal antiandrogen TSAA-291 and its cofactor recruitment profile. Eur J Pharmacol. 2015 Oct 15;765:322-31. doi: 10.1016/j.ejphar.2015.08.052. Epub 2015 Sep 1. Japanese. Japanese. Japanese. Japanese. Japanese. Japanese.
合成参考文献
摘要:Iyakuhin Kenkyu. Study of Medical Supplies., 12(1204), 1981
摘要:Yakuri to Chiryo. Pharmacology and Therapeutics., 7(937), 1979
摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 23(2291), 1981
摘要:Drugs in Japan, 6(157), 1982
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