CAS: 31277-98-2; Bis[1,2-Bis(Diphenylphosphino)Ethane]Palladium(0)

该化合物是一个协调综合体,其特点是钚,作为中央金属离子,与两种色素1,2-双(二苯磷)乙酯(dppf)相协调.该复合体的特点是平方平面平面几何学,典型的(0)复合物,由于dppf的酸性,2 具有相当大的稳定性.它经常被用作各种有机反应的催化剂,特别是苏木和斯蒂尔反应等交叉反应的催化剂,因为它能够促进形成碳-碳联结.二苯磷基的出现提高了中心的电子密度,促进了其再活性.此外,Pd(dppf)2因其在有机溶剂中的溶性而闻名,因此适合用于各种合成应用.它作为一种具有价值的合成工具,例如铃木和斯蒂尔反应的交叉反应,特别是作为一种具有交叉性反应的催化剂,因为它作为一种具有相对低的合成化学价值的复合工具,结合成了一个具有较低的合成的合成化学.

结构式图片

相似化合物

19978-61-1 59831-02-6 29964-62-3

欧盟法规

C&L通报

上下游产品

CAS号52522-40-4 三(二亚苄基丙酮)二钯,氯仿加合物 | CAS号14221-01-3 四(三苯基膦)钯(0) | CAS号1663-45-2 1,2-双(二苯基膦)乙烷 | CAS号6372-48-1 METHYLPHENYLPHO... | CAS号19978-61-1 双(二苯基磷)乙烷二氯化钯 | CAS号29364-29-2 2-甲基-2-丙硫醇钠盐 | CAS号163319-06-0

合成工艺路线路线简述

    Tris(Dibenzylideneacetone)Dipalladium(0) Chloroform Complex置于1,2-双(二苯基膦)乙烷体系中,用 苯 作为反应溶剂,以76%的收率获得产物双(1,2-双(二苯基膦)乙烷)钯
    参考文献:Granberg,Kenneth L.; Bäckvall,Jan-E.,Journal Of The American Chemical Society,1992,Vol. 114,# 17,P. 6858-6863
    标题:Granberg,Kenneth L.; Bäckvall,Jan-E.,Journal Of The American Chemical Society,1992,Vol. 114,# 17,P. 6858-6863

    专利信息


    专利号:US-9994567-B2
    优先权日:2015-05-22
    标 题:Synthesis of heterocyclic compounds
    发明人:IBRAHIM PRABHA N; LIN JACK; SPEVAK WAYNE; ZHANG JIAZHONG
    权利人:PLEXXIKON INC
    摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): n nor a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Q, P 1 and P 2 are as defined in this disclosure.

    专利号:US-8283476-B2
    优先权日:2007-06-26
    标 题:Transition metal catalyzed synthesis of 2H-indazoles
    发明人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS
    权利人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS; SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.

    专利号:US-8026375-B2
    优先权日:2007-04-13
    标题:Transition metal catalyzed synthesis of N-aminoindoles
    发明人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; RKYEK OMAR; URMANN MATTHIAS; ALONSO JORGE
    权利人:SANOFI AVENTIS
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

    专利号:US-8188282-B2
    优先权日:2006-07-15
    标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
    发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
    权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

    专利号:US-11059835-B2
    优先权日:2014-08-15
    标 题 :Synthesis of cephalosporin compounds
    发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
    权利人:MERCK SHARP & DOHME
    摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

    专利号:EP-2173747-B1
    优先权日:2007-06-26
    标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
    发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
    权利人:SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
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    合成参考文献


    摘要:Friesen, R. W., Science of Synthesis, (2001) 1, 210.
    摘要:Friesen, R. W., Science of Synthesis, (2001) 1, 245.
    摘要:Evano, G., Science of Synthesis, (2007) 20, 147.
    摘要:Evano, G., Science of Synthesis, (2007) 20, 144.
    摘要:Scott, P. J. H.; Steel, P. G., Science of Synthesis, (2008) 36, 487.
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