CAS: 2776-60-5; Methyl 2-(2-Aminoacetamido)Acetate Hydrochloride

相似化合物

556-50-3 39692-67-6 2087-41-4

上下游产品

CAS号53487-98-2 N-tert-butoxyca... | CAS号67-56-1 甲醇 | CAS号556-50-3 双甘肽 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号556-50-3 双甘肽 | CAS号31681-05-7 Glycine, glycyl...

📜Methyl 2-(2-Phthalimidoacetamido)Acetate置于盐酸体系中,用 乙醇,水 用作溶剂,化学反应 2.0H,反应生成甘氨酰甘氨酸甲酯盐酸盐
参考文献:Novel Thiazolidinedione-5-Acetic-Acid-Peptide Hybrid Derivatives As Potent Antidiabetic And Cardioprotective Agents
标题:Novel Thiazolidinedione-5-Acetic-Acid-Peptide Hybrid Derivatives As Potent Antidiabetic And Cardioprotective Agents
摘要:Thiazolidinediones (Tzds) Are One Of The Important Clinically Established Antidiabetic Agents. Aminoacid And Peptides Have An Advantage Of Better Target Selectivity And Specificity. As Hybrids,They Also Improved Absorption And Showed Better Bioavailability,Which In Turn Makes Them Safer. Hence,Here An Effort Has Been Made To Synthesize Hybrids Of Thiazolidinedione With Amino-Acids And Peptides And Evaluate Their Antidiabetic And Cardioprotective Effect In Streptozotocin-Nicotinamide (Stz-Na) Induced Type 2 Diabetes Mellitus (T2Dm) Rat Models.A Series Of 14 Thiazolidinedione-5-Acetic Acid Hybrids With Of Different Amino-Acids And Peptide Combinations Were Synthesized,Characterized And Further Screened For Antidiabetic And Cardioprotective Activity.Among All,Six Compounds T1 (Ssdma1),T4 (Ssdma4),T5 (Ssdma5),T7 (Sdma13),T9 (Ssdma15) And T13 (Ssdma49) Showed Better Antioxidant Activity And Comparable % Glucose Uptake By Yeast Cells.Hence,The In Vivo Antidiabetic Screening Was Done For These Six Compounds. Among All Six T1,T7,T13 Showed Significant Blood Glucose Level Decrease Compared To Standard Pioglitazone Hcl. Also T1,T7 And T13 Showed Better Antioxidant Activity With Lower Ic50 Value Than Standard Ascorbic Acid,And Hence In Vivo Cardioprotective Studies Were Done For These. The Ecg Studies Showed That T1 (Ssdma1) And T7 (Ssdma13) Were Better Effective Than Sdma49 (T13) In Restoring The Normal Functioning Of The Heart,Thus May Help In Preventing The Development Of Diabetic Cardiomyopathy (Dcm) And Controlling T2Dm. (C) C 2017 Elsevier Masson Sas. All Rights Reserved.
Doi:10.1016/j.Biopha.2017.01.160