CAS: 25522-33-2; (E)-3-(3-Hydroxy-4-Methoxyphenyl)Acrylic Acid

上下游产品

isovanillin malonic acid 3-amino-4-methoxy-cinnamic acid methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate dihydroisoferulic acid 3-(3-acetoxy-4-methoxyphenyl)acrylic acid methyl 3,4-dimethoxycinnamate

📜3-Iodo-4-Methoxy-Trans-Cinnamic Acid置于copper(I) Oxide,1-D-O-Methyl-Chiro-Inositol,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 6.0H,以81%的收率获得异阿魏酸
参考文献:铜和1-(-)-邻苯二酚在空气中催化芳基卤化物的羟基化和胺化
标题:铜和1-(-)-邻苯二酚在空气中催化芳基卤化物的羟基化和胺化
摘要:1-(-)-木瓜醇,一种从橡胶工业废水中获得的天然产物,被用作铜催化的羟基卤化和芳基卤化物胺化的有效配体,以选择性地在水中或95%的乙醇中生成酚和芳基胺.另外,在空气中以100G的规模验证了2-氯-4-羟基苯甲酸的羟基化.
Doi:10.1016/j.Tetlet.2020.152222

专利信息

专利号:US-8647848-B2
优先权日:2008-06-13
标题:Enzymatic synthesis of sphingolipids
发明人：HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-8263755-B2
优先权日:2006-11-20
标题:Synthesis of compounds useful as modulators of amyloid-beta production
发明人：FINDEIS MARK A
权利人:FINDEIS MARK A; SATORI PHARMACEUTICALS INC
摘要:As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-2017266353-A1
优先权日:2014-05-13
标 题:Bioadhesive compounds and methods of synthesis and use
发明人：MURPHY JOHN L; RADANO CHRISTOPHER P; DALSIN JEFFREY L; KOEPSEL JUSTIN T
权利人:DSM IP ASSETS BV
摘要:Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

专利号:US-7632972-B2
优先权日:2003-10-30
标 题 :Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells
发明人：HERGENROTHER PAUL J; NESTERENKO VITALIY; PUTT KARSON; ALLEN BRITTANY JOY; DOTHAGER ROBIN SHANE; LESLIE BENJAMIN JAMES
权利人:UNIV ALABAMA
摘要:Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.