CAS: 23893-13-2; Anhydroerythromycin A

该化合物是一种红细胞素的半合成衍生物,其特点是C6位置上没有水分子.这种改变增强了其在酸性条件下的稳定性,使其成为合成更强效大型滑动抗生素的宝贵中间体.其结构特性可以改善氯氟菊酯等某些衍生物的药动能.该化合物主要用于药物研究与开发,研究结构活动关系,优化抗生素功效.其明确界定的化学特征可以确保合成应用的再生性,支持基于大型滑动的治疗的进步.

结构式图片

MSDS等安全信息

上下游产品

erythromycin 9-deoxo-9-iminoerythromycin A erythromycin A erythromycin A enol ether

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:RU-2045533-C1
    优先权日:1990-07-18
    标 题 :O-methyl derivatives of azithromycin a showing antibacterial activity, azithromycins as intermediate compounds for synthesis of o-methyl derivatives of azithromycin a and a method of synthesis of o-methyl derivatives of azithromycin a

    专利号:US-2006074032-A1
    优先权日:2000-11-29
    标题 :Synthesis and separation of optically active isomers of erythromycin and their biological actions
    发明人:SOMBERG JOHN; RANADE VASANT
    权利人:ACADEMIC PHARM INC
    摘要:The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.

    专利号:WO-02064608-A1
    优先权日:2000-11-29
    标 题:Synthesis and separation of optically active isomers of erythromycin and their biological actions
    发明人:SOMBERG JOHN C; RANADE VASANT
    权利人:ACADEMIC PHARM INC; SOMBERG JOHN C; RANADE VASANT
    摘要:The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.

    专利号:CA-1209987-A
    优先权日:1981-11-27
    标 题:Chemical process for the synthesis of macrolide antibiotics

    专利号:FR-2517311-A1
    优先权日:1981-11-27
    标题 :CHEMICAL PROCESS FOR THE SYNTHESIS OF MACROLIDE ANTIBIOTICS

    专利号:RU-2130936-C1
    优先权日:1995-03-27
    标 题:9a-azalide fragments of macrolide antibiotics of azalide class, method of their synthesis and intermediate compounds for their synthesis

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    ✅ COA系统入驻 | 共享模式

    合成参考文献

    合成方法参考DOI号:10.1021/jo00382a004
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