CAS: 23155-02-4; Fosfomycin

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CAS号26016-99-9 磷霉素钠 | CAS号2041-14-7 2-氨基乙基膦酸 | CAS号22987-21-9 (2-羟基乙基)膦酸 | CAS号32986-56-4 妥布霉素

Phosphomycin Disodium Salt置于dowex 50X8,H(+)体系中,用 水 用作溶剂,化学反应生成磷霉素
参考文献:Studies On The Biodegradation Of Fosfomycin: Growth Of Rhizobium Huakuii Pmy1 On Possible Intermediates Synthesised Chemically
标题:Studies On The Biodegradation Of Fosfomycin: Growth Of Rhizobium Huakuii Pmy1 On Possible Intermediates Synthesised Chemically
摘要:R. Huakuii Pmy1 矿化磷霉素的第一步是水解开环,形成 (1R,2R)-1,2-二羟基丙基膦酸.通过化学方法合成了这种膦酸及其三种立体异构体,并测试了它们作为铵盐的矿化作用,Pi 的释放证明了这一点.只有 (1R,2R)-异构体被降解.化学合成了一些膦酸盐,如(+/-)-1,2-环氧丁基-,(+/-)-1,2-二羟乙基-,2-氧代丙基-,(S)-2-羟基丙基-,(+/-)-1-羟基丙基-和(+/-)-1-羟基-2-氧代丙基膦酸,但没有一种能支持生长.不过,在最后一种膦酸中检测到了体外 C-P 键裂解活性.由于亚磷酸不能用作磷源,因此必须放弃涉及亚磷酸的机制.R. Huakuii Pmy1 在(R)-和(S)-乳酸和羟基丙酮上生长非常好,但在丙酸上生长较差,在丙酮或(R)-和(+/-)-1,2-丙二醇上生长不良.从(1R,2R)-1,2-二羟基丙基膦酸中释放出的 Pi置于po3H2 组中标记了一个氧-18,但在细胞中停留的时间不够长,无法通过酶的转换将 18O 完全交换为 16O.
Doi:10.1039/b821829C

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-4937367-A
优先权日:1987-07-15
标 题:Process for the preparation of intermediates for the synthesis of fosfomycin
发明人：CASTALDI GRAZIANO; GIORDANO CLAUDIO
权利人:ZAMBON SPA
摘要:A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin. n More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R 2 and R 3 have the meanings reported in the specification.

专利号:US-2023323449-A1
优先权日:2021-12-17
标 题:Compositions and methods for detection of variants
发明人：GANTT RICHARD; ARNESON ADRIANA
权利人:TWIST BIOSCIENCE CORP
摘要:Testing the many hypotheses from genomics and systems biology experiments demands accurate and cost-effective gene and genome synthesis. Here we describe a microchip-based technology for multiplex gene synthesis. Pools of thousands of ‘construction’ oligonucleotides and tagged complementary ‘selection’ oligonucleotides are synthesized on photo-programmable microfluidic chips, released, amplified and selected by hybridization to reduce synthesis errors ninefold. A one-step polymerase assembly multiplexing reaction assembles these into multiple genes. This technology enabled us to synthesize all 21 genes that encode the proteins of the Escherichia coli 30S ribosomal subunit, and to optimize their translation efficiency in vitro through alteration of codon bias. This is a significant step towards the synthesis of ribosomes in vitro and should have utility for synthetic biology in general.

专利号:US-10899773-B2
优先权日:2014-12-19
标 题 :Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
发明人：NICOLAOU KYRIACOS C; CAI QUAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.