CAS: 201849-18-5; 5-Bromo-4-Chloro-2-Fluorotoluene
该化合物是一种芳香卤化合物,其特点是在甲基苯(聚苯乙烯)环上存在溴,氯和氟替代物.该化合物具有复杂的替代模式,其溴和氯原子分别位于1和2个位置,而氟原子位于4个位置,而氟原子位于苯环5个位置的甲基组,这些卤素的存在有助于其再活性,使其在各种化学合成过程中有用,特别是在制药和农用化学品生产中.该化合物可能由于电离子卤素原子而表现出中度至高度极性,影响其在有机溶剂中的溶解性.此外,它可能参与电药性芳香替代反应,其物理特性,例如沸腾和熔融点,将受到亚基化合物的蒸气和电子效应的影响.该化合物的存在将影响其再活性,使其在各种化学合成工艺中,特别是在制药和农用化学化学品生产过程中有用.该化合物的处理和储存中,安全数据将具有环境风险.
- 英文名称5-Bromo-4-Chloro-2-Fluorotoluene
- 中文名称5-溴-4-氯-2-氟甲苯
- IUPAC名称1-bromo-2-chloro-4-fluoro-5-methylbenzene
- 其它别名5-Bromo-4-Chloro-2-Fluorotoluene; 5-Bromo-4-Chloro-2-Fluorotoluene ; 5-Bromo-4-Chloro-2-Fluorotoluene; 1-Bromo-2-Chloro-4-Fluoro-5-Methylbenzene; Benzene, 1-Bromo-2-Chloro-4-Fluoro-5-Methyl-
- CAS编号201849-18-5
- MFCD编号:MFCD00143430
- 分子式:C7H5BrClF分子量:223.47
- 产品CID: 1025110
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
上下游产品
2-bromo-5-fluoro 4-methylaniline 2-chloro-4-fluoro-5-methylbenzoic acid 2-chloro-4-fluoro-5-methylbenzonitrile合成工艺路线路线简述
📜,亚硝酸丁酯,2-溴-5-氟-4-甲基苯胺,,盐酸置于乙醚,Magnesium Sulfate,正己烷体系中,用 乙腈 用作溶剂,化学反应 0.67H,以obtaining The Title Compound (5.6 G) As A Pale Yellow Oil的收率获得5-溴-4-氯-2-氟甲苯
参考文献:Pyridonecarboxylic Acid Derivatives Or Salts Thereof And Drugs
标题:Pyridonecarboxylic Acid Derivatives Or Salts Thereof And Drugs
摘要:本发明涉及一种以一般式(1)表示的吡啶酮羧酸衍生物:##str1##其中,R.Sup.1为--Oh,羧保护基或(烷基)氨基,R.Sup.2为h或--No.Sub.2,(保护的)氨基,(保护的)羟基,低级烷基或低级烷氧基,R.Sup.3为卤素原子,H或--No.Sub.2,低级烷基,低级烷氧基或氨基,R.Sup.4为偶氮基,(取代的)肼基,(取代的)氨基,低级烷氧基或羟基,R.Sup.5,R.Sup.6和r.Sup.7独立地为h,--No.Sub.2,卤素原子或低级烷基,R.Sup.8为--No.Sub.2,(取代的)氨基,--Oh或低级烷氧基,A为n或c--R.Sup.12,其中r.Sup.12为h,卤素原子或(取代的)低级烷基,低级烯基,低级炔基,低级烷氧基,低级烷硫基或硝基,B为n或c--R.Sup.13,其中r.Sup.13为h或卤素原子,或其盐,以及包含此类化合物作为活性成分的药物.该衍生物或其盐表现出优异的抗菌作用和口服吸收性,几乎不引起副作用,并且易于合成.
海关参考信息
- 2902300000-甲苯
2903919090-氯苯
2903991000-对氯甲苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6136823-A
优先权日:1996-11-28
标题 :Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
发明人：SAKAE NOBUYA; YAZAKI AKIRA; KURAMOTO YASUHIRO; YOSHIDA JIRO; NIINO YOSHIKO; OHSHITA YOSHIHIRO; HIRAO YUZO; HAYASHI NORIHIRO; AMANO HIROTAKA
权利人:WAKUNAGA PHARMA CO LTD
摘要:PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.
