CAS: 18370-10-0; 3-Chloro-N-Methylbenzamide

上下游产品

m-Chlorobenzoyl chloride methylamine propan-1-ol 3-chlorobenzoate H-tetrazole5-(3-chloro-phenyl)-1-methyl-1H-tetrazole 2-nitro-5-chlorobenzamide 7-methoxy-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 7-chloro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one

📜3-氯苯甲酸置于乙醚,五氯化磷体系中,化学反应生成3-氯-N-甲基苯甲酰胺
参考文献:Montagne,Recueil Des Travaux Chimiques Des Pays-Bas,1900,Vol. 19,P. 55
标题:Montagne,Recueil Des Travaux Chimiques Des Pays-Bas,1900,Vol. 19,P. 55

专利信息

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.