专利号:US-9382288-B2 优先权日:2010-10-06 标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action 发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO 权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG 摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
专利号:WO-2025086625-A1 优先权日:2023-10-26 标题 :Synthesis method for deuterated tinidazole 发明人:MEI SHU; GUO HUI; CHEN WULIAN 权利人:ANPEL LABORATORY TECH SHANGHAI INC 摘要:The present invention relates to a synthesis method for a deuterated tinidazole. The deuterated tinidazole is as represented by formula I, wherein one or more of R 1 -R 5 are deuterium, and the rest is hydrogen. The synthesis method comprises the step of oxidizing an intermediate B with m-chloroperoxybenzoic acid to prepare the deuterated tinidazole, wherein the oxidation is carried out under low-temperature and alkaline conditions; and the intermediate B is as represented by formula II. By using the synthesis method of the present invention, the problems of deuterium shedding and isotope dilution in the reaction process can be avoided, and the stable isotope-labeled deuterated tinidazole with the isotope abundance of > 98% is obtained with a higher yield. The prepared deuterated tinidazole can be used as an isotope internal standard reagent for the quantitative detection of tinidazole, which, for example, can be used to detect residual tinidazole in meat products by means of an isotope internal standard method, and has the advantages of having high recovery efficiency from a matrix, and being environmentally friendly and safe.
专利号:CN-117800993-B 优先权日:2023-07-03 标题 :Synthesis of zinc complex and application thereof in electrochemical detection of sulfadiazine
专利号:CN-117801027-A 优先权日:2023-07-03 标 题 :Synthesis of cobalt compound with spiral structure and application of cobalt compound in electrochemical detection
专利号:US-11135200-B2 优先权日:2014-12-20 标题:Antimicrobial drug synthesis and therapeutic compositions 发明人:GREGG JOHN MALCOLM HALL 权利人:GREGG JOHN MALCOLM HALL 摘要:This invention relates to the medical use of an antimicrobial agent, racemic Ornidazole, its (R) and (S) enantiomers, or pharmaceutically acceptable salts or esters thereof, and to methods of treatment which involve treating a subject with Ornidazole. The racemic (rac)-ornidazole, its enantiomers, or pharmaceutically acceptable salts or esters thereof, may be used in combination with other actives. The invention also relates to pharmaceutical formulations and compositions comprising (rac)-ornidazole, (R)-ornidazole, (S)-ornidazole, or pharmaceutically acceptable salts or esters thereof, and/or other actives as well as methods to stereoselectively manufacture the enantiomers.
专利号:US-9907753-B2 优先权日:2010-03-19 标 题 :Lipid vesicle compositions and methods of use 发明人:IRVINE DARRELL J; MOON JAEHYUN 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
1: Deka SR, Yadav S, Kumar D, Garg S, Mahato M, Sharma AK. Self-assembled dehydropeptide nano carriers for delivery of ornidazole and curcumin. Colloids Surf B Biointerfaces. 2017 Apr 20;155:332-340. doi: 10.1016/j.colsurfb.2017.04.036. [Epub ahead of print] doi: 10.1016/j.foodchem.2017.02.100. Epub 2017 Feb 22. Epub 2016 Sep 19. doi: 10.1002/jssc.201600382. doi: 10.1097/MD.0000000000004173. 8: Cakan H, Polat E, Arda O, Cepni I, Dirican A, Sirekbasan S. Morphological Changes of Trichomonas vaginalis Treated by Ornidazole: An In-Vitro Study. Clin Lab. 2016;62(5):793-800. Turkish. doi: 10.1016/j.cbi.2015.09.019. Epub 2015 Sep 26. doi: 10.1016/j.saa.2015.08.032. Epub 2015 Aug 22. doi: 10.5740/jaoacint.14-189. e7-8. doi: 10.1016/j.ajem.2015.03.022. Epub 2015 Mar 14. doi: 10.1021/am508712e. Epub 2015 Feb 18. doi: 10.1177/2050313X15621857. eCollection 2015. 16: Santra RC, Ganguly D, Singh J, Mukhopadhyay K, Das S. A study on the formation of the nitro radical anion by ornidazole and its significant decrease in a structurally characterized binuclear Cu(II)-complex: impact in biology. Dalton Trans. 2015 Jan 28;44(4):1992-2000. doi: 10.1039/c4dt03362k. doi: 10.4103/0019-5154.143591.
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664 摘要: 摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355