CAS: 16325-88-5; 2-Phenylpropane-2-Thiol

该化合物是一种含有硫磺的有机化合物,其特征是其独特的硫醇功能组,附于第三苯基碳.该甲卡普坦通常被用作有机合成的中间体,特别是在生产药品,农用化学品和特殊化学品方面.其发育障碍结构增强了稳定性,使其适合需要控制反应的反作用力.该化合物的强味,典型的为硫柳树,有助于检测泄漏应用.关键优势包括其高纯度,合成路径的一贯性能以及由于其手性中心而具有的非对称合成的实用性. 正确处理由于其反应性硫醇组和潜在挥发性,至关重要.

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6263-65-6 98-51-1 1012-72-2

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CAS号617-94-7 2-苯基-2-丙醇 | CAS号3457-58-7 2-nitropropan-2... | CAS号934-53-2 ALFA, ALFA-二甲基苄氯 | CAS号98-83-9 α-甲基苯乙烯

合成工艺路线路线简述

    📜过氧化二异丙苯置于劳森试剂,Cumylhydropersulfide体系中,用 甲苯,苯 用作溶剂,化学反应 3.0H,反应生成α,α-二甲基苄硫醇
    参考文献:氢过硫化物:H原子转移剂卓越
    标题:氢过硫化物:H原子转移剂卓越
    摘要:氢过硫化物(rssh)是通过气态生物递质硫化氢(h 2 S)与二硫化物(rssr)和/或亚磺酸(rsoh)的反应内生形成的.研发了rssh在体内储存h 2 S的能力以及作为抗氧化应激的防御线,从中可以清楚地看出,Rssh对二电子氧化剂的反应性比硫醇更高.在此,我们描述了对rssh的h原子转移化学的研究结果,并将其与众所周知的硫醇的h原子转移化学进行了对比.事实上,Rssh优异h-原子供体,以烷基(ķ〜5x10 8中号-1小号-1),烷氧基(ķ〜1x10 9中号-1小号-1),过氧化氢(ķ〜2x10 6中号-1小号-1),和含硫(ķ > 1x10 10中号-1小号-1)自由基,对硫醇的抑制作用可低至1个数量级,最高可至4个数量级.Rssh对h原子转移的固有高反应性很大程度上是基于热力学因素.较弱的rss-h键解离焓(〜70 Kcal / Mol)和相关的高硫基自由基稳定性使上述反应放热15-34
    Doi:10.1021/jacs.7B02571

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    专利信息


    专利号:US-2014275582-A1
    优先权日:2013-03-14
    标 题 :Chiral 2-arylpropyl-2-sulfinamide and chiral n-2-arylpropyl-2-sulfinylimines and synthesis thereof
    发明人：LI GUIGEN
    权利人:LI GUIGEN; UNIV TEXAS TECH; NANJING UNIVERSITY INST OF CHEMISTRY AND BIOMEDICAL SCIENCES
    摘要:Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.

    专利号:US-9216953-B2
    优先权日:2012-11-02
    标题 :Chiral 2-arylpropyl-2-sulfinamide and chiral N-2-arylpropyl-2-sulfinylimines and synthesis thereof
    发明人：LI GUIGEN; PINDI SURESH
    权利人:LI GUIGEN; PINDI SURESH
    摘要:Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.

    专利号:CN-105130857-B
    优先权日:2015-09-25
    标题:A class of double sulfoxide compounds and their synthesis methods and applications

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    合成参考文献


    参考文献:10.1007/bf00604073
    摘要:Yablonskii OP, Rodionova NM, Lapuka LF. An infrared spectroscopic study of hydrogen bonding in thiols. Journal of Applied Spectroscopy. 1973 Oct;19(4):1303–5. doi: 10.1007/bf00604073.
    参考文献:10.1007/bf00604095
    摘要:Morozov YV, Avanov AY, Lomakin AY, Savin FA, Florent'ev VL, Padyukova NS, Styrov VV, Popov DP, Sokolov VA, Yablonskii OP, Lapuka LF, Rodionova NM, Zalukaev LP, Vorob'eva RP, Oleinikova TA, Shmyreva ZV, Kotorlenko LA, Samoilenko SA, Nazarova ZN, Babeshkina LD, Shelepin OE. Abstracts. Journal of Applied Spectroscopy. 1973 Oct;19(4):1376–8. doi: 10.1007/bf00604095.
    参考文献:10.1007/bf00614601
    摘要:Yablonskii OP, Lapuka LF, Rodionova NM, Mazaev VE, Kotorlenko LA, Samoilenko SA, Klima MI, Karelin AI, Dement'ev VA. NMR and infrared spectroscopic study of the association of 2-phenylpropane-2-thiol. Journal of Applied Spectroscopy. 1973 Sep;19(3):1244–6. doi: 10.1007/bf00614601.
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