CAS: 150256-42-1; Fmoc-2-Abz-Oh

该化合物是一种化学化合物,其特点是,含有一种与氨氨氨丙酸组相连的氟-九-甲基碳酸(Fmoc)保护组(Fmoc),该化合物通常作为氨基功能的保护组用于浸泡合成,允许有选择的反应,而不会干扰其他功能组.N-Fmos-anthranic酸是白色的,可以溶于二甲基硫氧化物(DMF)和二甲基二亚硫化物(DIF)等有机溶剂中,但一般在水中溶解,其结构中含有炭疽酸基,其中包括氨基和炭本酸基酸基基,有助于其在有机合成中的再活动性和效用.

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CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号118-92-3 邻氨基苯甲酸 | CAS号4424-17-3 4-甲氧基-3-氨基苯酰替苯胺 | CAS号18543-23-2 2-benzamido-N-p... | CAS号89369-45-9 ethyl 2-[[2-[(m...

合成工艺路线路线简述

    📜氯甲酸-9-芴基甲酯,邻氨基苯甲酸置于碳酸氢钠体系中,用 1,4-二氧六环,水 用作溶剂,以90%的收率获得fmoc-2-氨基苯甲酸
    参考文献:通过含烟酸同源物扩展 Myxochelin 天然产物家族
    标题:通过含烟酸同源物扩展 Myxochelin 天然产物家族
    摘要:粘细菌是化学多样性和生物活性次生代谢物的可行来源.粘螯素是一个经过充分研究的儿茶酚酸盐型铁载体家族,由各种粘细菌菌株产生.在这里,我们报告了来自陆地粘杆菌珊瑚球菌属的三种新粘螯素 N1-N3 的发现,分离和结构阐明. Mcy9049,具有不寻常的烟酸部分.进行前体定向生物合成 (Pdb) 实验和全合成,以确认结构,提高获得纯化合物进行生物活性测试的机会,并制定生物合成方案.对涵盖粘细菌的代谢组和基因组数据的综合评估支持这样的观点,即本文报道的新粘螯素同系物实际上是粘细菌中已知的粘螯素 A 生物合成途径的常见副产物.
    Doi:10.3390/molecules26164929

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    专利信息


    专利号:US-9211296-B2
    优先权日:2007-02-06
    标题:Therapeutic compounds for blocking DNA synthesis of POX viruses
    发明人：RICCIARDI ROBERT P
    权利人:UNIV PENNSYLVANIA
    摘要:This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula I, formula XXI, formula XXXII, or formula XLI which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula I, formula XXI, formula XXXII, or formula XLI can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.

    专利号:WO-2009008906-A2
    优先权日:2007-02-06
    标 题:Therapeutic compounds for blocking dna synthesis of pox viruses

    专利号:US-2010035887-A1
    优先权日:2007-02-06
    标题:Therapeutic compounds for blocking dna synthesis of pox viruses

    专利号:US-2013338117-A1
    优先权日:2007-02-06
    标 题:Therapeutic compounds for blocking dna synthesis of pox viruses

    专利号:US-2012322770-A1
    优先权日:2007-02-06
    标题 :Therapeutic compounds for blocking dna synthesis of pox viruses

    专利号:US-8278342-B2
    优先权日:2007-02-06
    标 题:Therapeutic compounds for blocking DNA synthesis of pox viruses

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    主要参考文献

    参考标题:Total Synthesis Of The Cyclic Pentapeptides Pf1171B, D, E, And Avellanins A, B, C With Inhibitory Activity Against Apolipoprotein B Production
    作者:Masaya Honda,Minoru Inagaki,Yuichi Masuda |发布日期:2021.9
    摘要:The Total Synthesis Of Pf1171B, D, And E, And Avellanins A, B, And C, Which Are Cyclic Pentapeptides Containing Non-Proteinogenic Amino Acid Residues, Was Achieved By Solid-Phase Peptide Elongation And Solution-Phase Macrolactamization. Pf1171B And D And Avellanins A And C Were Found To Inhibit Apolipoprotein B Production In Hep G2 Cells Without Exhibiting Cytotoxicity. Pf1171B Had The Most Potent

    合成参考文献


    参考文献:10.1557/s43578-025-01683-8
    摘要:Verma N, Mahato M, Dhawan U, Kumar P. Exploring tunable characteristics of anthranilic acid in peptide-based nanostructures. J. Mater. Res. 2025 Sep 02;40(18):2615–26. doi: 10.1557/s43578-025-01683-8.
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