CAS: 131775-99-0; 1-Cyclopropyl-7-(4-Ethylpiperazin-1-yl)-6-Fluoroquinolin-4(1H)-One

该化合物是乙型氟化烃丙烷的一种代谢物,一种广泛用于兽医药物的氟丙酮抗生素,它保留了重要的抗菌活动,特别是针对克格朗阴性病原体和一些克格伦阳性病原体的抗菌活动;安诺福辛的脱色信箱增强了其稳定性和生物利用率,使其成为分析研究的有用参考标准;该化合物对于制药动力学和残留物监测研究,确保准确量化生物样本中乙型氟化辛及其代谢物,具有宝贵的价值;其精细的特性有助于HPLC和LC-MS分析方法的发展,支持遵守食品安全和兽用药物监测的监管标准.

英文名称1-Cyclopropyl-7-(4-Ethylpiperazin-1-yl)-6-Fluoroquinolin-4(1H)-One
中文名称脱羧恩氟沙星
IUPAC名称1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one
其它别名Decarboxy Enrofloxacin; 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-4(1H)-Quinolinone; Enrofloxacin Ep Impurity F; Enrofloxacin Impurity 6(Enrofloxacin Ep Impurity F); 1-Cyclopropyl-7-(4-Ethylpiperazin-1-yl)-6-Fluoroquinolin-4-One; Enrofloxacin Impurity F(Ep); 1-Cyclopropyl-7-(4-Ethylpiperazin-1-yl)-6-Fluoroquinolin-4(1H)-One; 4(1H)-Quinolinone, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-
CAS编号131775-99-0
MFCD编号:MFCD01310445
FDA UNII编号:58SB45FT52
分子式:C18H22FN3O分子量:315.39
产品CID: 484608
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: MHZWALDGPXSPGF-UHFFFAOYSA-N
InChI=1S/C18H22FN3O/c1-2-20-7-9-21(10-8-20)17-12-16-14(11-15(17)19)18(23)5-6-22(16)13-3-4-13/h5-6,11-13H,2-4,7-10H2,1H3
计算化学: 氢键受体数5.0氢键供体数0.0可旋转键数3.0

MSDS等安全信息

上下游产品

enrofloxacin

合成工艺路线路线简述

📜恩诺沙星置于potassium Cyanide体系中,用 N,N-二甲基甲酰胺用作溶剂,化学反应 24.0H,以65%的收率获得脱羧恩氟沙星
参考文献:Preparation And Antibacterial Evaluation Of Decarboxylated Fluoroquinolones
标题:Preparation And Antibacterial Evaluation Of Decarboxylated Fluoroquinolones
摘要:Decarboxylated Ciprofloxacin (3) Has Been Reported In The Literature To Have Antibacterial Activities Against Staphylococcus Aureus,Staphylococcus Epidermidis,Enterococcus Faecalis,Bacillus Subtilis,Enterobacter Cloacae,Serratia Marcescens And Especially Potent Activity Against Escherichia Coli. Herein,We Report Our Syntheses Of 3 And Five Additional Decarboxylated Fluoroquinolones (Fqs). We Have Re-Evaluated The Antibacterial Activity Of These Fqs. In Contrast To Previously Reported Data,None Of These Decarboxylated Fluoroquinolones Showed Significant Antibacterial Activity In Our Assays Using Both The Broth Dilution And Agar Methods. Our Study Confirmed That The Presence Of A Carboxylic Acid Group At The 3-Position Of The Fluoroquinolone Scaffold Is Essential For Antibacterial Activity. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.07.060

海关参考信息

2921211000-乙二胺
2933310010-吡啶
2901100000-饱和无环烃
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

Brown, S., et al.: J. Vet. Pharmacol. Ther., 19, 1 (1996), Vitha, M., et al.: J. Phys. Chem., 100, 18823 (1996), Torniainen, K., et al.: Pharm. Biomed. Anal., 15, 887 (1997),

合成参考文献

参考文献:10.1016/j.bmcl.2011.07.060
摘要:Nguyen ST, Ding X, Butler MM, Tashjian TF, Peet NP, Bowlin TL. Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. Bioorganic & Medicinal Chemistry Letters. 2011 Oct;21(19):5961–3. doi: 10.1016/j.bmcl.2011.07.060.