CAS: 131666-45-0; Ethyl 8-Hydroxy-5-Methyl-6-Oxo-5,6-Dihydro-4H-Benzo[f]Imidazo[1,5-A][1,4]Diazepine-3-Carboxylate

上下游产品

Ethyl is°Cyanoacetate 6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione 2-Amino-5-methoxybenzoic acid 7-methoxy-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione

5-甲氧基靛红酸酐置于三溴化硼,Sodium Hydride体系中,用 四氢呋喃,二氯甲烷,二甲基亚砜,N,N-二甲基甲酰胺,Mineral Oil 用作溶剂,化学反应 20.0H,反应生成脱氟8-羟基氟马西尼
参考文献: [18 F]-Labelled Analogues Of Flumazenil As In Vivo Imaging Agents[fr] Analogues Du Flumazénil Marqués Au Fluor 18 En Tant Qu'Agents D'Imagerie In Vivo
标题: [18 F]-Labelled Analogues Of Flumazenil As In Vivo Imaging Agents[fr] Analogues Du Flumazénil Marqués Au Fluor 18 En Tant Qu'Agents D'Imagerie In Vivo
摘要:本发明提供了用于体内成像gabaa受体的放射性氟化合物.本发明还提供了一种用于合成所述放射性氟化合物的方法,特别是一种自动合成方法.本发明的另一个方面是一种适用于执行本发明的自动合成方法的盒式装置.

专利信息

专利号:US-2012189547-A1
优先权日:2009-10-08
标 题 :[18f] labelled analogues of flumazenil as in vivo imaging agents
发明人：WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
权利人:WOODCRAFT JOHN; JONES CLARE L; GAETA ALESSANDRA; TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER; PLANT STUART
摘要:The present invention provides radiofluorinated compounds useful for in vivo imaging GABA A receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automated method of synthesis. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention.