CAS: 1181267-38-8; Methyl 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-Benzo[d]Imidazol-2-yl)Piperidin-1-yl)Ethyl)Phenyl)-2-Methylpropanoate

该化合物是一种合成中间体,产自不分离的抗脊髓灰质炎,主要用于制药研发,以发挥优化合成二甲肝和相关化合物的作用,其主要优势包括高化学稳定性,有利于受控反应,提高有机溶剂的溶性,有利于高效净化和配方工艺;酯功能组还允许有选择地进行修改,提高药物设计的多样性;Butastal Ester因其一贯纯度和可再生性而备受重视,使其成为生产具有精确药性,基于二甲胺的治疗器的可靠前体.

英文名称Methyl 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-Benzo[d]Imidazol-2-yl)Piperidin-1-yl)Ethyl)Phenyl)-2-Methylpropanoate
中文名称比拉斯汀杂质16
IUPAC名称methyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate
其它别名Benzeneacetic Acid, 4-[2-[4-[1-(2-Ethoxyethyl)-1H-Benzimidazol-2-Yl]-1-Piperidinyl]Ethyl]-α,α-Dimethyl-, Methyl Ester; Bilastine Impurity 16; Methyl 2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-Benzo[d]Imidazol-yl)Piperidin-1-yl)Ethyl)Phenyl)-2-Methylpropanoate; Bilastine Impurity 8 Oxalate; Methyl 2-[4-[2-[4-[1-(2-Ethoxyethyl)-2-Benzimidazolyl]-1-Piperidyl]Ethyl]Phenyl]-2-Methylpropanoate; Methyl Bilastine; Pilastine 8; Bilastine Ester
CAS编号1181267-38-8
MFCD编号:MFCD20267178
分子式:C29H39N3O3
分子量:477.65
产品CID: 231574
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: AWUXQUVYMUBJSG-UHFFFAOYSA-N
InChI=1S/C29H39N3O3/c1-5-35-21-20-32-26-9-7-6-8-25(26)30-27(32)23-15-18-31(19-16-23)17-14-22-10-12-24(13-11-22)29(2,3)28(33)34-4/h6-13,23H,5…
计算化学: 氢键受体数5.0氢键供体数*可旋转键数11.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P501-

上下游产品

2-Ethoxyethyl methanesulphonate 2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester Bilastine

合成工艺路线路线简述

2-(4-哌啶)-1H-苯并咪唑置于盐酸,水,Sodium Hydride,N,N-二异丙基乙胺,Sodium Hydroxide体系中,用四氢呋喃,1,4-二氧六环,水,N,N-二甲基甲酰胺用作溶剂,化学反应 35.0H,反应生成比拉斯汀杂质16
参考文献:Alternative Synthesis Of Bilastine
标题:Alternative Synthesis Of Bilastine
摘要:[image Omitted] A New And Efficient Synthesis Of The Non-Sedating Histamine H1 Receptor Antagonist Bilastine Is Reported. The New Route Employs A Convergent Strategy,With A Longest Linear Sequence Of Five Steps,Giving Slightly Improved Yields Over The Previous Routes. The Use Of Anhydrous Metal-Halogen Exchange,Hazardous Ethylene Oxide,And A Tedious Protection Of The Carboxylic Acid Function Are All Avoided.
Doi:10.1080/00397911.2010.486506