CAS: 110964-79-9; 4-(Methylsulfonyl)-2-Nitrobenzoic Acid

相似化合物

393085-45-5 849035-66-1 773873-23-7

上下游产品

1‐methyl‐4‐(methylsulfonyl)‐2‐nitrobenzene 4-chlorosulfonyl-2-nitro-benzoic acid chloroacetic acid Methyl p-tolyl sulfone 2-amino-4-(methylsulfonyl)benzoic acid 4-methylsulphonyl-2-nitrobenzoyl chloride 3-(4'-methylsulfonyl-2'-nitro-benzoyloxy)-2-cyclohexene-1-one 4-nitrophenyl 2-nitro-4-(methylsulfonyl)benzoate

2-硝基-4-甲砜基氯苯置于双氧水,Potassium Hydroxide,Sodium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应 3.0H,反应生成2-硝基-4-甲砜基苯甲酸
参考文献:Preparative Method For Carboxylic Acids
标题:Preparative Method For Carboxylic Acids
摘要:本发明公开了一种羧酸的制备方法.该方法的特点在于:在过氧化氢和碱的存在下,化合物(II)发生反应,生成目标产物(i),如下面的反应方案所示:其中r1为芳基,吡啶基,嘧啶基,吡啶并嘧啶基,吡嗪基,苯并噻吩基,苯并呋喃基,喹啉基,异喹啉基,噻二唑基,C1-6烷基,C3-6环烷基,C2-6烯基,C2-6炔基和氢;R2为烷氧羰基,烷基氨基羰基,氨基羰基,烷基硫醇羰基,氰基,磺酰基,亚砜基,羰基,醛基,羧基,硝基,烷基和氢;R3为烷氧羰基,烷基酰胺羰基,氨基羰基,氰基,磺酰基,亚砜基,羰基,羧基和硝基.本发明具有以下主要优点:起始原料廉价且易得,工艺安全,产率高,质量好,有利于工业生产.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-11008285-B2
优先权日:2017-03-27
标 题 :Process for synthesis of mesotrione
发明人：GHARDA KEKI HORMUSJI; MATHUR SUCHET SARAN; JAIN NANDKUMAR JANARDAN; SATHE SHEKHAR VISHWANATH; DAMANIA PRAGNESH DALPATRAM
权利人:GHARDA CHEMICALS LTD
摘要:The present disclosure relates to a process for synthesis of mesotrione. The process comprises reacting 4-toluene sulfonyl chloride with alkali metal sulphite and alkali metal bicarbonate to obtain alkali metal toluene-4-sulfinate. The alkali metal toluene-4-sulfinate is reacted with alkali metal salt of monochloroacetic acid to obtain 4-methylsulfonyl toluene. Further, 4-methylsulfonyl toluene is nitrated to obtain 2-nitro-4-methylsulfonyl toluene. 2-nitro-4-methylsulfonyl toluene is oxidized and then halogenated to obtain 2-nitro-4-methylsulfonylbenzoyl halide. 2-nitro-4-methylsulfonylbenzoyl halide is reacted with alkali metal salt of 1,3-cyclohexanedione to obtain 3-(2-Nitro-4-methylsulfonylbenzoyloxy)cyclohexen-1-one which is reacted with base, a third fluid medium and cyanide ion source to obtain an amorphous mesotrione. The present disclosure also discloses the steps of converting the amorphous mesotrione to crystalline mesotrione having purity greater than 99%. The process of the present disclosure for preparing mesotrione is rapid, economic, and environment friendly.

专利号:US-2023303487-A1
优先权日:2020-07-31
标 题 :Process for preparation of mesotrione and its intermediates
发明人：PANIRAJ A S; KUMAR SURESH D; S V R ADITHYA
权利人:RALLIS INDIA LTD
摘要:The present disclosure provides a new and improved process for preparation of intermediate compounds and synthesis of mesotrione therefrom. The present disclosure provides an economical, efficient and eco-friendly process for preparation of mesotrione.

专利号:CN-112300033-B
优先权日:2020-11-03
标题:A device and synthesis method for fully continuous synthesis of 2-nitro-4-methylsulfonyl benzoic acid from 4-methylsulfonyltoluene

专利号:US-2023128195-A1
优先权日:2017-07-06
标 题:Synthesis of halichondrins

专利号:CN-118515685-A
优先权日:2017-07-06
标题 :Synthesis of halichondrin