CAS: 1032-65-1; ((2R,3S,5R)-5-(4-Amino-2-Oxopyrimidin-1(2H)-yl)-3-Hydroxytetrahydrofuran-2-yl)Methyl Dihydrogen Phosphate

相似化合物

13085-50-2 151151-32-5 63-37-6

上下游产品

CAS号951-77-9 2’-脱氧胞苷 | CAS号58781-41-2 N4-benzoyl-2'de... | CAS号17182-39-7 N4-benzoyl-3'-O... | CAS号18531-20-9 2'-Deoxy-5'-O-(... | CAS号23339-46-0 5'-dApdC-3' | CAS号116113-40-7 | CAS号71-30-7 胞嘧啶 | CAS号13009-95-5 5-hydroxymethyl... | CAS号951-77-9 2’-脱氧胞苷 | CAS号2056-98-6 2'-脱氧胞苷三磷酸

(2R,3S,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-yl)-2-(Hydroxymethyl)Tetrahydrofuran-3-Yl Acetate置于ammonium Hydroxide,Tps-Taz体系中,用 吡啶,水 用作溶剂,化学反应 9.0H,反应生成2'-脱氧胞苷-5'-单磷酸
参考文献:核苷磷酸化的新方法
标题:核苷磷酸化的新方法
摘要:开发了一种新的磷酸化试剂2-O-(4,4'-二甲氧基三苯甲基)乙基磺酰lethan-2'-基磷酸酯(1),用于磷酸化核苷的伯醇和仲醇.在许多研究的实例中,磷酸化步骤的收率非常好(约80%至95%).该方法不仅在核苷和核苷酸化学中,而且在诸如碳水化合物和氨基酸的生物分子的磷酸化中都有广泛的应用潜力.
Doi:10.1016/s0040-4039(00)01251-X

专利信息

专利号:EP-1309698-B1
优先权日:2000-07-21
标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
发明人：CAHOON EDGAR B
权利人:DU PONT
摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

专利号:US-8058414-B2
优先权日:2008-04-29
标题 :Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
发明人：MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI
权利人:MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI; LIFE TECHNOLOGIES CORP
摘要:Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described.

专利号:US-8314209-B2
优先权日:2007-12-12
标 题 :Lipid-assisted synthesis of polymer compounds and methods for their use
发明人：RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO
权利人:RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO; UNIV CALIFORNIA
摘要:The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The method comprises providing an aqueous solution having a plurality of phospholipid molecules and monomer molecules; subjecting the aqueous solution to fluctuating temperature conditions; subjecting the aqueous solution to fluctuating cycles of drying and hydrating conditions; subjecting the aqueous solution to fluctuating [H + ] conditions; the fluctuating conditions thereby allowing formation of a chemical bond between at least two monomers to create a polymer. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

专利号:WO-2004113530-A1
优先权日:2003-06-18
标题:Polynucleotide for synthesis of labeled protein
发明人：NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
权利人:MITSUBISHI CHEM CORP; NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
摘要:A process for producing a labeled protein, comprising translating a gene template in the presence of a labeled compound having a label portion consisting of a labeled substance and an acceptor portion consisting of a compound capable of binding to the C-terminus of protein synthesized by a translation system. In particular, there are provided a polynucleotide for use in synthesis of labeled protein characterized by having the capability of enhancing labeling efficiency through addition to the 3’ end of a base sequence coding for target protein within the gene template and provided a process for producing a labeled protein that is carried out with the use of the polynucleotide.

专利号:WO-2023031333-A1
优先权日:2021-09-01
标 题:Polymeric soluble support, process for the synthesis thereof and uses thereof
发明人：RANDRIANJATOVO-GBALOU IRINA; SAID AHMED; KEBE SEYDINA IBRAHIMA
权利人:SYNHELIX
摘要:The present invention relates to a process for the synthesis of an organic molecule, comprising the use of a polymeric soluble support. The invention further relates to the polymeric soluble support, and to a process for the synthesis thereof.

专利号:US-9267213-B1
优先权日:2005-03-25
标题:Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
发明人：MAURER KARL; COOPER JOHN J
权利人:CUSTOMARRAY INC
摘要:There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.