CAS: 1006-39-9; 1-(2-Bromo-4-Fluorophenyl)Ethanone

相似化合物

704909-66-0 127371-55-5 928715-37-1

上下游产品

CAS号403-42-9 对氟苯乙酮 | CAS号7789-45-9 溴化铜 | CAS号1073-06-9 间溴氟苯 | CAS号108-24-7 乙酸酐 | CAS号261711-20-0 1-(2-溴-4-氟苯基)乙醇

2-溴-4-氟苯甲醛置于pyridinium Chlorochromate体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成2-溴-4-氟苯乙酮
参考文献:苯乙酮n-甲苯磺酰and与乙烯基的分子内反应:布朗斯台德酸促进阳离子环化成多取代茚
标题:苯乙酮n-甲苯磺酰and与乙烯基的分子内反应:布朗斯台德酸促进阳离子环化成多取代茚
摘要:在存在tsnhnh 2的情况下,开发了布朗斯台德酸促进的邻-(1-芳基乙烯基)苯乙酮衍生物的分子内环化反应,导致多取代的茚并酮具有复杂性和多样性,产率中等至优异.与自由基或卡宾涉及醛基n-甲苯磺酰hydr与乙烯基的环化形成鲜明对比,涉及阳离子环化途径,其中n-甲苯磺酰zone在该转化过程中用作亲电试剂和烷基化试剂.
Doi:10.1039/d0Cc07966A

专利信息

专利号:US-6800477-B2
优先权日:2001-03-22
标 题:Stereoselective reduction of substituted acetophenone
发明人：PATEL RAMESH; GOSWAMI ANIMESH; CHU LINDA N; NANDURI VENKATA B; GOLDBERG STEVEN L; JOHNSTON ROBERT M; DONOVAN MARY JO; MIRFAKHRAE K DAVID
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of gamma-secretase useful in the treatment of Alzheimer's disease.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:US-6852711-B2
优先权日:1998-09-11
标题:HIV protease inhibitors
发明人：BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:AGOURON PHARMA
摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

专利号:ES-2302452-A1
优先权日:2006-11-24
标题 :PROCEDURE FOR THE SYNTHESIS OF ARIL TIOETERES DERIVATIVES.

专利号:CN-1371903-A
优先权日:2001-02-28
标 题 :Optical isomers, synthesis and analgesic activity of 3-methylfentanyl derivatives