CAS: 957198-30-0; 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyrimidin-2-yl)Morpholine

该化合物是一种黄酸衍生物,具有独特的结构特征,包括一个以甲状腺素组和乙醇酯酸酯替代的火利米丁环,通常具有与黄酸有关的特性,例如能够与二醇和其他核糖核酸形成可逆共价联系,使其在各种化学反应中有用,包括铃木在有机合成中的混合反应; 甲状醇组的存在会增加其在极地溶剂中的溶性,并可能影响其生物活动,有可能在药用化学中成为药用药用磷,此外,酸酯的功能可以提供稳定性,促进在某些条件下对黄酸的处理; 总的来说,由于合成有机化学和制药研究具有多种特性,这种复合物在药物开发中具有潜在用途.

英文名称4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyrimidin-2-yl)Morpholine
中文名称2-(4-吗啡啉基)嘧啶-5-硼酸嚬哪醇酯
IUPAC名称4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)morpholine
其它别名2 - (4 - 吗啉)嘧啶-5 - 硼酸频哪醇酯; 9 2-(4-Morpholino)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS编号957198-30-0
MFCD编号:MFCD07368246
EINECS号:894-071-2
分子式:C14H22BN3O3
分子量:291.15
产品CID: 2011546
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: HNVAYPJNFUXYII-UHFFFAOYSA-N
InChI=1S/C14H22BN3O3/c1-13(2)14(3,4)21-15(20-13)11-9-16-12(17-10-11)18-5-7-19-8-6-18/h9-10H,5-8H2,1-4H3…
计算化学: 氢键受体数6.0氢键供体数0可旋转键数2

相似化合物

870521-33-8 1015242-07-5 1015242-00-8

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn
危险类别码22

欧盟法规

C&L通报

上下游产品

4-(5-bromopyrimidin-2-yl)morpholine bis(pinacol)diborane 4-[5-(2-bromo-phenyl)pyrimidin-2-yl]morpholine ethyl 2-(3-(4-((3-(2-morpholinopyrimidin-5-yl)benzyl)oxy)phenyl)oxetan-3-yl)acetate

合成工艺路线路线简述

1352796-65-6 = 957198-30-0
反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Tetrahydrofuran; 24 H,80 °C
标题:Preparation Of Guanidine Derivatives As Vap-1 Inhibitors
参考文献:World Intellectual Property Organization]

84539-22-0 + 73183-34-3 = 957198-30-0
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; Overnight,85 °C
标题:Preparation Of 1,2,4-Triazole Derivative And Their Medical Application As Anticancer Agents
参考文献:World Intellectual Property Organization]

73183-34-3 + 32779-36-5 = 957198-30-0
反应条件:1.1 Solvents: Acetonitrile,Tetrahydrofuran; 1 H,Rt1.2 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 100 °C
标题:Preparation Of Pyridinyl Derivatives,Pharmaceutical Compositions And Uses Thereof As Selective Aoc3 Inhibitors
参考文献:World Intellectual Property Organization]

84539-22-0 + 73183-34-3 = 957198-30-0
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; Overnight,90 °C; 90 °C -> Rt
标题:Heteroaryl Compounds As Protein Kinase Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

73183-34-3 = 957198-30-0
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; Overnight,100 °C1.2 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: Dimethylformamide,1,4-Dioxane; Overnight,95 °C
标题:Sulfonyl-Substituted Benzoheterocyclic Derivative As Ezh2 Inhibitor And Its Preparation
参考文献:World Intellectual Property Organization]

84539-22-0 + 73183-34-3 = 957198-30-0
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: Dimethylformamide; Overnight,80 °C
标题:Process For Preparation Of 1,5,7-Tri-Substituted Isoquinoline Derivatives And Use In Medicines
参考文献:World Intellectual Property Organization]

84539-22-0 + 61676-62-8 = 957198-30-0
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; -78 °C; 30 Min,-78 °C1.2 2 H,-78 °C; -78 °C -> Rt1.3 Reagents: Ammonium Chloride Solvents: Water; Rt
标题:Pyrrole Derivatives Useful For The Treatment Of Cytokine-Mediated Diseases And Their Preparation
参考文献:World Intellectual Property Organization

5-溴-2-(吗啉-1)嘧啶,联硼酸频那醇酯置于1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物,Potassium Acetate体系中,用 1,4-二氧六环作为反应溶剂,以65.7%的收率获得产物2-(4-吗啡啉基)嘧啶-5-硼酸嚬哪醇酯
参考文献: 1,2,4-Triazole Derivative And Preparation Method Therefor And Use Thereof[fr] Dérivé De 1,2,4-Triazole,Son Procédé De Préparation Et Son Utilisation[zh] 1,2,4-三氮唑衍生物及其制备方法和用途
标题: 1,2,4-Triazole Derivative And Preparation Method Therefor And Use Thereof[fr] Dérivé De 1,2,4-Triazole,Son Procédé De Préparation Et Son Utilisation[zh] 1,2,4-三氮唑衍生物及其制备方法和用途
摘要:提供一种1,2,4-三氮唑衍生物及其制备方法和用途,所述1,2,4-三氮唑衍生物为式i所示的化合物,或其旋光异构体,对映体,非对映体,外消旋体或外消旋混合物,或其溶剂合物,前药,或其药学上可接受的盐;所述的化合物可用于治疗多种不当的核转运触发的异常细胞应答相关的疾病,紊乱或病症.