CAS: 943541-20-6; 3-Chloro-6-(1-Methyl-1H-Pyrazol-4-yl)Pyridazine

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相似化合物

1211519-08-2 2613436-80-7 1467445-44-8

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上下游产品

3,6-dichlorpyridazine 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 3-chloro-6-iodopyridazine 3-chloro-6-(1-trityl-1H-pyrazol-4-yl)pyridazine JNJ-38877605 3-[3-(5-bromopyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine 6-(1-methyl-1H-pyrazol-4-yl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-1,2,4-triazolo[4,3-b]pyridazine 3-{[3-(5-bromopyrimidin-2-yl)phenyl]difluoromethyl}-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine

合成工艺路线路线简述

  • 1211519-08-2 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Catalysts: 18-Crown-6 Solvents: Diethyl Ether; 20 Min,Rt; Rt -> 0 °C1.2 0 °C; Overnight,0 °C -> Rt
    标题:1,2,4-Triazolo[4,3-B]Pyridazine Derivatives As Highly Selective C-Met Kinase Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    141-30-0 + 269410-08-4 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane,Water; 5 H,90 °C
    标题:Discovery Of Substituted Pyrazol-4-Yl Pyridazinone Derivatives As Novel C-Met Kinase Inhibitors
    作者:Kim,Eun-Young; Kang,Seung-Tae; Jung,Heejung; Park,Chi Hoon; Yun,Chang-Soo; Et Al
    参考文献:Archives Of Pharmacal Research 日期:2016 卷标:39(4) 页码:453-464]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane,Water; 2.5 H,80 °C; 80 °C -> Rt
    标题:Preparation Of Triazolopyridazine Protein Kinase Modulators
    参考文献:World Intellectual Property Organization]

    135034-10-5 + 761446-44-0 = 943541-20-6
    反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane; Rt -> 80 °C; 3 H,80 °C
    标题:Preparation Of Pyridazinones As Antitumor Agents
    参考文献:World Intellectual Property Organization]

    = 943541-20-6 [标题:Reaction Conditions
    标题:Preparation Of Polymorphic And Hydrate Forms,Salts Of 6-[difluoro[6-(1-Methyl-1H-Pyrazol-4-Yl)[1,2,4]Triazolo[4,3-B]Pyridazin-3-Yl]Methyl]Quinoline For Treatment Of Cell Proliferative Disorder
    参考文献:United States]

    = 943541-20-6 [标题:Reaction Conditions
    标题:Preparation Of Pyridazinones As Antitumor Agents
    参考文献:Germany]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane,Water; 10 H,90 °C
    标题:Preparation Of Quinoline Derivatives As Parp-1 And C-Met Dual-Target Inhibitors For Treating Cancer
    参考文献:China]

    135034-10-5 + 761446-44-0 = 943541-20-6
    反应条件:1.1 Reagents: Benzyltriethylammonium Chloride,Triphenylphosphine,Tripotassium Phosphate Catalysts: Palladium Diacetate Solvents: Tetrahydrofuran,Water; 16 H,65 °C; 65 °C -> 60 °C1.2 Reagents: Sodium Chloride Solvents: Water; 15 Min,60 °C; 60 °C -> 45 °C
    标题:Preparation Of Polymorphic And Hydrate Forms,Salts Of 6-[difluoro[6-(1-Methyl-1H-Pyrazol-4-Yl)[1,2,4]Triazolo[4,3-B]Pyridazin-3-Yl]Methyl]Quinoline For Treatment Of Cell Proliferative Disorder
    参考文献:World Intellectual Property Organization]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane,Water; 4 H,80 °C
    标题:Preparation Of Bicyclic Triazoles As Protein Kinase Modulators
    参考文献:World Intellectual Property Organization]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane,Water; Rt -> 80 °C; 10 H,80 °C
    标题:Preparation Of Quinoline Derivatives As C-Met Inhibitors For Treatment Of Cancer
    参考文献:China]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,4-Dioxane,Water; Overnight,Rt -> 80 °C
    标题:Preparation Of Triazolopyridazines As Tyrosine Kinase Modulators
    参考文献:World Intellectual Property Organization]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane,Water; 16 H,80 °C
    标题:Preparation Of 6-(1-Methyl-1H-Pyrazol-4-Yl)-3-(2-Methyl-2H-Indazol-5-Ylthio)-[1,2,4]Triazolo[4,3-B]Pyridazine As Antitumor Agent
    参考文献:World Intellectual Property Organization]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: 1,4-Dioxane; 1 Min,Rt1.2 Catalysts: Dichlorobis(Triphenylphosphine)Palladium; 15 H,80 °C
    标题:Preparation Of A Novel Deuterated Triazolopyridazine As C-Met Kinase Inhibitor For Treating Cancer
    参考文献:World Intellectual Property Organization]

    = 943541-20-6
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Methanol; Rt; Rt -> 50 °C; 2 H,40 - 50 °C1.2 Solvents: Dichloromethane,Water; 30 Min,40 - 50 °C1.3 Solvents: Tert-Butyl Methyl Ether; 1 H,Rt
    标题:Preparation Method Of Pyrazole Compound And Its Intermediates
    参考文献:China]

    761446-44-0 + 141-30-0 = 943541-20-6
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,4-Dioxane,Water; 5 H,100 °C
    标题:Preparation Of Substituted Piperidinyl-Pyridazinyl Derivatives As Scd1 Inhibitors
    参考文献:World Intellectual Property Organization]

    135034-10-5 + 761446-44-0 = 943541-20-6
    反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane; Rt -> 80 °C; 3 H,80 °C
    标题:Preparation Of Triazolo[4,3-B]Pyridazines As Met Kinase Inhibitors
    参考文献:World Intellectual Property Organization]

    135034-10-5 + 761446-44-0 = 943541-20-6
    反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane; Rt -> 80 °C; 3 H,80 °C; 80 °C -> Rt
    标题:Pyridazinone Derivatives As Met Kinase Inhibitors And Their Preparation And Use In The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    = 943541-20-6 [标题:Reaction Conditions
    标题:Preparation Of Triazolo[4,3-B]Pyridazines As Met Kinase Inhibitors
    参考文献:Germany
📜3-氯-6-甲基哒嗪置于草酰氯,Sodium Carbonate体系中,用 甲醇,氯仿 作为反应溶剂,化学反应 4.0H,反应生成 3-氯-6-(1-甲基-1H-4-吡唑基)哒嗪
参考文献:吡唑类化合物的制备方法及其中间体
标题:吡唑类化合物的制备方法及其中间体
摘要:本发明公开了一种吡唑类化合物的制备方法及其中间体.本发明具体公开了化合物b的制备方法.本发明的制备方法可以取得以下一个或多个优点:操作简单,收率较高,成本低,适合工业化生产.

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合成参考文献


参考文献:10.1007/s12272-015-0703-7
摘要:Kim E, Kang S, Jung H, Park CH, Yun C, Hwang JY, Byun BJ, Lee CO, Kim HR, Ha JD, Ryu DH, Cho SY. Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors. Archives of Pharmacal Research. 2016 Jan 11;39(4):453–64. doi: 10.1007/s12272-015-0703-7.
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