CAS: 86318-61-8; Tert-Butyldimethylsilylacetylene

该化合物是一种有机硅化合物,其特点是,在乙炔细胞中有一个附着的三丁基二甲基硅合金组;该化合物一般是无色的,在标准条件下以其稳定性而闻名;该化合物的沸点相对较低,对小型有机分子来说很常见;该二丁基二甲基硅合金组增加了该化合物的疏水性,并提供了消毒障碍,使其在各种合成应用中有用,特别是在有机合成中,并作为化学反应中功能组的保护组.乙炔功能组的存在允许进一步的再活性,通过混合反应形成碳-碳联系.此外,(乙酰二甲基硅)乙烷可用于制作更复杂的分子,包括药品和农用化学品.在处理该化合物时,应当采取安全防范措施,因为它可能构成与易燃性和潜在毒性相关的风险.

结构式图片

相似化合物

107474-02-2 89343-06-6 29681-57-0

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号18162-48-6 叔丁基二甲基氯硅烷 | CAS号74-86-2 乙炔 | CAS号4301-14-8 乙炔基溴化镁 | CAS号120789-51-7 3-叔丁基二甲基甲硅烷基-2-... | CAS号886-66-8 1,4-二苯基丁二炔 | CAS号67875-55-2 1,3-双(1,1-二甲基乙基... | CAS号90083-19-5 3-TERT-BUTYLDIM...

合成工艺路线路线简述

  • 18162-48-6 = 86318-61-8
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 1 H,-78 °C1.2 30 Min,-78 °C; -78 °C -> Rt; 24 H,Rt
    标题:Synthesis And Use Of New Substituted 1,3,5-Hexatrienes In Studying Thermally Induced 6π-Electrocyclizations
    作者:Suennemann,Hans Wolf; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2007 卷标:(23) 页码:3879-3893]

    18162-48-6 = 86318-61-8
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran1.2 -
    标题:Bulky Trialkylsilyl Acetylenes In The Cadiot-Chodkiewicz Cross-Coupling Reaction
    作者:Marino,Joseph P.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2002 卷标:67(19) 页码:6841-6844]

    18162-48-6 + 4301-14-8 = 86318-61-8
    反应条件:1.1 Solvents: Hexamethylphosphoramide
    标题:Thioketene Syntheses. Vii. Substituent Effects On The Thio-Claisen Rearrangement Of Alkynyl Allyl Sulfides
    作者:Schaumann,Ernst; Et Al
    参考文献:Chemische Berichte 日期:1983 卷标:116(5) 页码:1728-38]

    18162-48-6 = 86318-61-8
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran
    标题:The Stereochemistry Of Organometallic Compounds. Xxxvi. Regio- And Stereochemical Control In The Nickel-Catalyzed Hydrocyanation Of Silylalkynes
    作者:Fitzmaurice,Neil J.; Et Al
    参考文献:Journal Of Organometallic Chemistry 日期:1985 卷标:285(1-3) 页码:375-81]

    107474-01-1 = 86318-61-8 [标题:Reaction Conditions
    标题:Regio- And Stereoselective Synthesis Of Ynenamides Through Gold(I)-Catalyzed Hydroalkynylation Of Ynamides
    作者:Siera,Hannah; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(34)]

    925-90-6 + 18162-48-6 = 86318-61-8
    反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 4 H,Rt; Overnight,Rt
    标题:Silylation Of Alcohols,Phenols,And Silanols With Alkynylsilanes - An Efficient Route To Silyl Ethers And Unsymmetrical Siloxanes
    作者:Kucinski,Krzysztof; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2020 卷标:2020(26) 页码:4042-4049]

    72726-45-5 + 1066-54-2 = 86318-61-8 [标题:Reaction Conditions
    标题:Regio- And Stereoselective Synthesis Of Ynenamides Through Gold(I)-Catalyzed Hydroalkynylation Of Ynamides
    作者:Siera,Hannah; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(34)
📜Tert-Butyldimethyl((Trimethylsilyl)Ethynyl)Silane置于potassium Carbonate体系中,化学反应生成 (叔丁基二甲基)乙炔
参考文献:通过金(i)催化的亚酰胺的区域选择性和立体选择性合成亚硝基酰胺
标题:通过金(i)催化的亚酰胺的区域选择性和立体选择性合成亚硝基酰胺
摘要:使用金 (I) 催化剂,可以将带有不同取代基的末端乙炔添加到炔酰胺中.氢化炔基化反应具有高度的区域选择性和立体选择性.实验和量子化学计算揭示了一种通过双金催化的机制.
DOI:10.1002/ejoc.202200591

海关参考信息

专利信息


专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-2006172914-A1
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

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合成参考文献


摘要:Baker, A.; Wirth, T., Science of Synthesis Knowledge Updates, (2017) 1, 196.
摘要:Jackowski, O.; Perez-Luna, A., Science of Synthesis Knowledge Updates, (2022) 3, 74.
摘要:Larsen, M. H.; Cacciarini, M.; Brøndsted Nielsen, M., Science of Synthesis Knowledge Updates, (2015) 2, 254.
摘要:Ipaktschi, J.; Saidi, M. R., Science of Synthesis Knowledge Updates, (2012) 4, 438.
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