CAS: 84-52-6; (2R,3S,4R,5R)-5-(4-Amino-2-Oxopyrimidin-1(2H)-yl)-4-Hydroxy-2-(Hydroxymethyl)Tetrahydrofuran-3-Yl Dihydrogen Phosphate

该化合物是一种核酸,在各种生物过程中,特别是在合成RNA过程中,起着关键作用,包括细胞基,糖和与糖的3欧元位置相连的磷酸盐组;该化合物是形成RNA线的关键构件,在转录过程中与guanine相配;3 欧元-CMP在水中溶解,有利于其参与生物化学反应;它还参与细胞信号传输途径,可以作为各种酶的基质,包括动脉酶和聚合酶.磷酸组的存在有助于其酸性,使其在生理pH中成为负电分子.此外,3 欧元-CMP可磷酸,形成高能核糖,这是细胞中能源转移和储存所必不可少的.其结构特征和功能作用使它成为分子生物学和生物化学的重要分子.

英文名称(2R,3S,4R,5R)-5-(4-Amino-2-Oxopyrimidin-1(2H)-yl)-4-Hydroxy-2-(Hydroxymethyl)Tetrahydrofuran-3-Yl Dihydrogen Phosphate
中文名称胞啶3'-单磷酸
IUPAC名称(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate
其它别名Cytidine-3'(2')-Monophosphoric Acid; Cytidine 3'-Monophosphate; 3'-Cytidylic Acid; 3-Cytidylic Acid; 3'-Cmp; Cytidine 3'-Monophosphate Free Acid; Cytidine-3'-Monophosphoric Acid; 3μ-Cmp, 3μ-Cytidylic Acid
CAS编号84-52-6
MFCD编号:MFCD00006543
EINECS号:201-537-5
FDA UNII编号:6DZL5I6D4D
分子式:C9H14N3O8P分子量:323.2
产品CID: 1833974
产品分类生物化工 → 核苷类药物 → 核苷中间体

相似结构搜索
InChIKey: UOOOPKANIPLQPU-XVFCMESISA-N
InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
计算化学: 氢键受体数8.0氢键供体数5.0可旋转键数4.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338-
UN编号HAZARD
WGK Germany3

上下游产品

合成工艺路线路线简述

97997-74-5 = 84-52-6 [标题:Reaction Conditions
标题:Chemical Synthesis Of Branched Oligoribonucleotides
作者:Sekine,Mitsuo; Et Al
参考文献:Bulletin Of The Chemical Society Of Japan 日期:1991 卷标:64(2) 页码:588-601]

2536-99-4 = 84-52-6 + 65-46-3
反应条件:1.1 Reagents: Cupric Chloride Solvents: Dimethyl Sulfoxide,Water; Ph 8.8,50 °C
标题:Ribonuclease Activity Of An Artificial Catalyst That Combines A Ligated Cuii Ion And A Guanidinium Group At The Upper Rim Of A Cone-Calix[4]Arene Platform
作者:Salvio,Riccardo; Et Al
参考文献:Journal Of Organic Chemistry 日期:2015 卷标:80(11) 页码:5887-5893]

2536-99-4 = 84-52-6 + 65-46-3 + 85-94-9
反应条件:1.1 Reagents: 4-(2-Hydroxyethyl)-1-Piperazineethanesulfonic Acid Catalysts: Manganese,Dichloro(2,2′:6′,2′′-Terpyridine-Kn1,Kn1′,Kn1′′)-,(Sp-5-12)- Solvents: Water; 21 H,Ph 7.0,50 °C1.2 Reagents: Phosphoric Acid Solvents: Water
标题:Hydrolysis Of Di-Ribonucleoside Monophosphate Diesters Assisted By A Manganese(Ii) Complex
作者:Yashiro,Morio; Et Al
参考文献:Bulletin Of The Chemical Society Of Japan 日期:2003 卷标:76(9) 页码:1813-1817]

633-90-9 = 84-52-6
反应条件:1.1 Solvents: Water
标题:Studies On Polynucleotides. Xxxiv. The Specific Synthesis Of C3'-C5'-Linked Ribooligonucleotides. New Protected Derivatives Of Ribonucleosides And Ribonucleoside 3'-Phosphates. Further Syntheses Of Diribonucleoside Phosphates
作者:Lohrmann,R.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1964 卷标:86(19) 页码:4188-94]

633-90-9 = 84-52-6
反应条件:1.1 Catalysts: α-Cyclodextrin
标题:Cooperation Of Cyclodextrin And Alkali-Metal Halide For Regioselective Cleavage Of Ribonucleoside 2',3'-Cyclic Phosphates
作者:Komiyama,Makoto; Et Al
参考文献:Journal Of The American Chemical Society 日期:1992 卷标:114(3) 页码:1070-4]

633-90-9 = 84-52-6 + 85-94-9
反应条件:1.1 Reagents: Tetrasodium 25,26,27,28-Tetrahydroxycalix[4]Arene-5,11,17,23-Tetrasulfonate Solvents: Water
标题:Water-Soluble Calixarene As The First Man-Made Catalyst For Regioselective Cleavage Of Ribonucleoside 2',3'-Cyclic Phosphate
作者:Komiyama,Makoto; Et Al
参考文献:Chemistry Letters 日期:1991 卷标:(6) 页码:937-40]

633-90-9 = 84-52-6 + 85-94-9
反应条件:1.1 Catalysts: β-Cyclodextrin Solvents: Water
标题:Regioselective Phosphorus-Oxygen(3') Cleavage Of 2',3'-Cyclic Monophosphates Of Ribonucleosides Catalyzed By β- And γ-Cyclodextrins
作者:Komiyama,Makoto; Et Al
参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(20) 页码:4936-9]

633-90-9 = 84-52-6 + 85-94-9
反应条件:1.1 Catalysts: β-Cyclodextrin,6A-[[2-[(2-Aminoethyl)Amino]Ethyl]Amino]-6A-Deoxy- (Transition Metal Complexes) Solvents: Water
标题:Efficient Cleavages Of Ribonucleoside 2',3'-Cyclic Phosphates And Ribonucleotide Dimers Catalyzed By β-Cyclodextrin Attached With Diethylenetriamine-Zinc(Ii) Complex
作者:Komiyama,Makoto; Et Al
参考文献:Chemistry Letters 日期:1989 卷标:(5) 页码:719-22]

65-46-3 = 84-52-6 + 63-37-6 + 85-94-9
反应条件:1.1 Reagents: Uridine Solvents: Water
标题:Interaction Between N-Phospho-Amino Acids And Nucleoside In Aqueous Medium
作者:Zhao,Yu Fen; Et Al
参考文献:Chinese Chemical Letters 日期:2000 卷标:11(5) 页码:407-408

📜胞苷-2'-磷酸置于formic Acid Buffer体系中,化学反应生成胞啶3'-单磷酸
参考文献:Oivanen,Mikko; Loennberg,Harri,Acta Chemica Scandinavica,1990,Vol. 44,# 3,P. 239-242
标题:Oivanen,Mikko; Loennberg,Harri,Acta Chemica Scandinavica,1990,Vol. 44,# 3,P. 239-242

海关参考信息

2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-8470987-B2
优先权日:2009-09-16
标题:Protective group for synthesis of RNA and derivative
发明人：WADA TAKESHI; SHIMIZU MAMORU
权利人:WADA TAKESHI; SHIMIZU MAMORU; CHIRALGEN LTD
摘要:A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2â€²-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R 1 and R 2 both represent hydrogen atom, or represent a halogen atom, a C 1-6 alkyl group, or a C 1-6 halo-substituted alkyl group; R 3 and R 4 represent hydrogen atom, a halogen atom, a C 1-6 alkyl group, or a C 1-6 halo-substituted alkyl group; and R 5 and R 6 represent a halogen atom, a C 1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.

专利号:US-2020239500-A1
优先权日:2018-04-04
标题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:WO-2025103457-A1
优先权日:2023-11-17
标题:Sirna for inhibiting lpa expression and use thereof
发明人：ZHANG JIETING; ZHAO WEIFENG; LI QIANG; YIN PEIXIU; CHEN PU
权利人:NANOPEPTIDE QINGDAO BIOTECHNOLOGY LTD
摘要:An siRNA duplex molecule for inhibiting LPA (apo(a)) gene expression, an siRNA-GalNAc delivery vector conjugate, and an application thereof. By means of forming a silencing complex, complementarily pairing with an LPA (apo(a)) mRNA sequence, and causing mRNA degradation, the siRNA inhibits LPA (apo(a)) expression; the siRNA can specifically reduce liver cell synthesis of LPA, providing treatment of a cardiovascular-related disease.

专利号:US-10144928-B2
优先权日:2013-08-23
标题:Double stranded oligonucleotide compounds comprising positional modifications
发明人：AVKIN-NACHUM SHARON; FEINSTEIN ELENA; BEIGELMAN LEONID
权利人:QUARK PHARMACEUTICALS INC
摘要:Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof.

专利号:KR-20060129026-A
优先权日:2004-01-27
标题 :Ribonucleic acid compound and method of liquid-phase synthesis of oligonucleic acid compound