CAS: 796875-53-1; 4-(Tert-Butyl)-2-Ethoxybenzoic Acid

该化合物是一种有机化合物,其特点是其苯酸结构,其特点是附于苯环的碳本体酸功能组,该化合物包括一个叔丁基组(1,1-二甲基乙基)和一个乙氧组,其特性是独特的.这一结构传播了疏水特性,使其在水中较少溶解,但在有机溶剂中更易溶解.乙氧组的存在增强了其再活动性和有机合成的潜在应用.该化合物可能展示生物活动,使其在制药和农用化学研究中引起兴趣.其熔点,沸点和特定再活动将取决于分子相互作用和研究中的环境.与许多有机化合物一样,应参考安全数据,以了解其处理情况和潜在危害.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

carbon dioxide 1-bromo-2-ethoxy-4-(tert-butyl)benzene 2-bromo-5-(1,1-dimethylethyl)phenol 3-tert-butylphenyol 4-tert-butyl-2-ethoxybenzoyl chloride 2-(4-tert-butyl-2-ethoxyphenyl)-cis-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole hydr°Chloride N-2-amino-1-(4-chlorophenyl)ethyl-4-tert-butyl-2-ethoxybenzamide 2-(4-tert-butyl-2-ethoxyphenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-imidazole

合成工艺路线路线简述

  • 20942-68-1 = 796875-53-1
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; Rt -> Reflux; 3 H,Reflux; Reflux -> Rt2.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C2.2 40 °C; 40 °C -> Reflux; 4 H,Reflux; Reflux -> -20 °C2.3 -20 °C; -20 °C -> Rt; Overnight,Rt2.4 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Small Molecules Simultaneously Inhibiting P53-Murine Double Minute 2 (Mdm2) Interaction And Histone Deacetylases (Hdacs): Discovery Of Novel Multitargeting Antitumor Agents
    作者:He,Shipeng; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2018 卷标:61(16) 页码:7245-7260]

    585-34-2 = 796875-53-1
    反应条件:1.1 Reagents: Bromine Solvents: Dichloromethane; 15 Min,< 35 °C1.2 Reagents: Sodium Bisulfite Solvents: Water; 5 Min,< 35 °C2.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; 8 H,Reflux3.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C; Reflux; 2.5 H,Reflux; Reflux -> -20 °C3.2 -20 °C; -20 °C -> Rt; Overnight,Rt3.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:A Practical Synthesis Of A Cis-4,5-Bis(4-Chlorophenyl)Imidazoline Intermediate For Nutlin Analogs
    作者:Shu,Lianhe; Et Al
    参考文献:Organic Process Research & Development 日期:2012 卷标:16(11) 页码:1866-1869]

    1418005-59-0 = 796875-53-1
    反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C1.2 40 °C; 40 °C -> Reflux; 4 H,Reflux; Reflux -> -20 °C1.3 -20 °C; -20 °C -> Rt; Overnight,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Small Molecules Simultaneously Inhibiting P53-Murine Double Minute 2 (Mdm2) Interaction And Histone Deacetylases (Hdacs): Discovery Of Novel Multitargeting Antitumor Agents
    作者:He,Shipeng; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2018 卷标:61(16) 页码:7245-7260]

    1418005-59-0 = 796875-53-1
    反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C; Reflux; 2.5 H,Reflux; Reflux -> -20 °C1.2 -20 °C; -20 °C -> Rt; Overnight,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:A Practical Synthesis Of A Cis-4,5-Bis(4-Chlorophenyl)Imidazoline Intermediate For Nutlin Analogs
    作者:Shu,Lianhe; Et Al
    参考文献:Organic Process Research & Development 日期:2012 卷标:16(11) 页码:1866-1869]

    20942-68-1 = 796875-53-1
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; 8 H,Reflux2.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C; Reflux; 2.5 H,Reflux; Reflux -> -20 °C2.2 -20 °C; -20 °C -> Rt; Overnight,Rt2.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:A Practical Synthesis Of A Cis-4,5-Bis(4-Chlorophenyl)Imidazoline Intermediate For Nutlin Analogs
    作者:Shu,Lianhe; Et Al
    参考文献:Organic Process Research & Development 日期:2012 卷标:16(11) 页码:1866-1869]

    585-34-2 = 796875-53-1
    反应条件:1.1 Reagents: Diazomethane Solvents: Dichloromethane; 30 Min,0 °C1.2 Reagents: Sodium Bisulfite Solvents: Water; 10 Min,0 °C2.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; Rt -> Reflux; 3 H,Reflux; Reflux -> Rt3.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C3.2 40 °C; 40 °C -> Reflux; 4 H,Reflux; Reflux -> -20 °C3.3 -20 °C; -20 °C -> Rt; Overnight,Rt3.4 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Small Molecules Simultaneously Inhibiting P53-Murine Double Minute 2 (Mdm2) Interaction And Histone Deacetylases (Hdacs): Discovery Of Novel Multitargeting Antitumor Agents
    作者:He,Shipeng; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2018 卷标:61(16) 页码:7245-7260
📜3-叔丁基苯酚置于potassium Tert-Butylate,溴,碘,Magnesium体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 10.5H,反应生成 2-乙氧基-4-叔丁基苯甲酸
参考文献:实用合成的nutlin类似物的顺式-4,5-双(4-氯苯基)咪唑啉中间体
标题:实用合成的nutlin类似物的顺式-4,5-双(4-氯苯基)咪唑啉中间体
摘要:报道了nutlin类似物的关键中间体顺式-4,5-双(4-氯苯基)咪唑啉的实用合成.硼酸催化内消旋-双(4-氯苯基)乙烷-1,2-二胺与苯甲酸的直接缩合反应制得标题化合物,产率为81-88%.该工艺已在中试工厂成功扩大规模,产生了超过15千克的产品.
DOI:10.1021/op300254Q

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参考文献:10.1007/s00128-011-0336-6
摘要:Malhat F, Hassan A. Level and Fate of Etoxazole in Green Bean (Phaseolus vulgaris). Bulletin of Environmental Contamination and Toxicology. 2011 Jun 11;87(2):190–3. doi: 10.1007/s00128-011-0336-6.
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