CAS: 73489-84-6; Diethyl 3-Hydroxy-3-Methylpentanedioate
- 英文名称Diethyl 3-Hydroxy-3-Methylpentanedioate
- 中文名称3-羟基-3-甲基-戊二酸二乙酯
- IUPAC名称diethyl 3-hydroxy-3-methylpentanedioate
- 其它别名3-Hydroxy-3-Methyl-Glutaric Acid Diethyl Ester ,; 3-Hydroxy-3-Methylglutaric Acid Diethyl Ester; Diethyl 3-Hydroxy-3-Methylglutarate; 3-Hydroxy-3-Methylpentanedioic Acid Diethyl Ester; Iethyl3-Hydroxy-3-Methylpentanedioate; Pentanedioic Acid, 3-Hydroxy-3-Methyl-, 1,5-Diethyl Ester
- CAS编号73489-84-6
- MFCD编号:MFCD11215453
- EINECS号:277-481-0
- 分子式:C10H18O5分子量:218.25
- 产品CID: 1721962
- 产品分类化学试剂 → 有机试剂 → 酯类
物理性质
MSDS等安全信息
上下游产品
CAS号503-49-1 美格鲁托 | CAS号75-03-6 碘乙烷 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号105-39-5 氯乙酸乙酯 | CAS号105-36-2 溴乙酸乙酯 | CAS号25201-40-5 1,1-二烯丙基乙醇 | CAS号503-49-1 美格鲁托 | CAS号87894-65-3 3-ACETOXY-3-MET... | CAS号67116-19-2 4-甲基-2H-吡喃-2,6(...合成工艺路线路线简述
📜1,1-二烯丙基乙醇置于硫酸,双氧水,Potassium Carbonate,臭氧,溶剂黄146体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 19.0H,反应生成 3-羟基-3-甲基-戊二酸二乙酯
参考文献:3-Alkyl-3-Hydroxyglutaric Acids: A New Class Of Hypocholesterolemic Hmg Coa Reductase Inhibitors. 1
标题:3-Alkyl-3-Hydroxyglutaric Acids: A New Class Of Hypocholesterolemic Hmg Coa Reductase Inhibitors. 1
摘要:Derivatives Of 3-Hydroxy-3-Methylglutaric Acid (Hmg),A Portion Of The Substrate For Hmg Coa Reductase,Were Prepared And Tested For Their Inhibitory Action Against Rat Liver Hmg Coa Reductase And For Their Hypocholesterolemic Activity. Structure-Dependent Competitive Inhibition Was Observed. Optimal Structures Had A Free Dicarboxylic Acid With An Alkyl Group Of 13-16 Carbons At Position 3. 3-N-Pentadecyl-3-Hydroxyglutaric Acid (3J) (Ic50 = 50 Microm) Reduced Serum Cholesterol In The Triton-Treated Rat And Hmg Coa Reductase Activity In The 20,25-Diazacholesterol-Treated Rat.
DOI:10.1021/jm50001A011
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399001-1,3-丙二醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:A Biomimetic Synthesis Of Polycyclic Polyoxygenated Aromatic Compounds Via Polyketides作者:Masahiko Yamaguchi,Koichi Hasebe,Toru Minami
摘要:Polyoxygenated Naphthalenes, Anthracenes And A Naphthacene Are Synthesized From Glutarates And Acetoacetate Dianion Via Polyketides.
合成参考文献
参考文献:10.1021/jm50001a011
摘要:Baran JS, Laos I, Langford DD, Miller JE, Jett C, Taite B, Rohrbacher E. 3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1. J Med Chem. 1985 May;28(5):597–601. doi: 10.1021/jm50001a011.
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