CAS: 733036-94-7; Tafluprost Impurity 7

上下游产品

(5Z,13E)-(9S,11R,15RS)-15-fluoro-9-hydroxy-16-phenoxy-11-(tetrahydropyran-2-yloxy)-17,18,19,20-tetranor-5,13-prostadienoic acid isopropyl ester (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate [3aR,4R(1E,3RS),5R,6aS]-4-(3-fluoro-4-phenoxy-1-buten-1-yl)-5-hydroxy-hexahydro-2H-cyclopenta[b]furan-2-one [3aR,4R(1E,3RS),5R,6aS]-4-(3-fluoro-4-phenoxy-1-buten-1-yl)-5-(tetrahydropyran-2-yloxy)-hexahydro-2H-cyclopenta[b]furan-2-ol

📜他氟前列素中间体置于盐酸,(+)-β-Chlorodiisopinocampheylborane,二乙胺基三氟化硫,Potassium Tert-Butylate,二异丁基氢化铝,对甲苯磺酸,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 四氢呋喃,二氯甲烷,水,异丙醇,丙酮,甲苯 作为反应溶剂,化学反应 14.5H,反应生成 拉坦前列素杂质7
参考文献:15-Fluoro Prostaglandin Fp Agonists: A New Class Of Topical ocular Hypotensives
标题:15-Fluoro Prostaglandin Fp Agonists: A New Class Of Topical ocular Hypotensives
摘要:A Novel Series Of 15-Fluoro Prostaglandins With Phenoxy Termination Of The Omega-Chain Was Synthesized And Evaluated For Binding And Functional Activation Of The Prostaglandin Fp Receptor In Vitro And For Side Effect Potential And Topical ocular Hypotensive Efficacy In Vivo. Compounds With The 15Alpha-Fluoride Relative Stereochemistry Displayed Ec50 Values Of Less Than Or Equal To 20 Nm,Comparable To The Value For The Endogenous Ligand Pgf(2Alpha). Evaluation Of Selected Ester Prodrugs Of These 15-Fluoro Prostaglandins In Vivo Highlighted Their Generally Low Propensity To Elicit Hyperemia Or ocular Irritation In Rabbits And Efficacious Intraocular Pressure-Lowering Property In Monkeys. In Particular 13,14-Dihydro-15-Deoxy-15Alpha-Fluoro-16-Aryloxy-Omega-Tetranor-Cis-Delta(4)-Pgf(2Alpha) Isopropylester (24) Caused Relatively Little ocular Irritation In Rabbits While Lowering Intraocular Pressure In Conscious ocular Hypertensive Monkeys By 39% Following A Topical ocular Dose Of 3 Mug. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2004.04.034