CAS: 6452-47-7; Methylcarbamic Chloride

上下游产品

phosgene methylamine hydr°Chloride methylamine methyl is°CyanateEthyl N-methylcarbamate methyl is°Cyanate N-Methylcarbamoyl-isoxazol-3-on 1-Methyl-3-[3-(2-p-tolyl-ethoxy)-phenyl]-urea

异氰酸甲酯置于盐酸体系中,用 四氯化碳 作为反应溶剂,化学反应生成 甲胺基甲酰氯
参考文献:链脲佐菌素的制备合成.
标题:链脲佐菌素的制备合成.
摘要:Abstractdurch Umsetzung Von D‐glucosamin Mit Dem Bisher Unbekannten N‐nitroso‐methylcarbamylazid (Vii) Wurde Das Beta‐zytotoxin Streptozotocin (Viii) Synthetisch Präparativ Zugänglich Gemacht.
DOI:10.1002/hlca.19690520837

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-8026395-B1
优先权日:2008-05-27
标 题:Process for the synthesis of anti-neoplasia agent VNP40101M
发明人：LIN XU; KING IVAN
权利人:NANOTHERAPEUTICS INC
摘要:The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.

专利号:US-9884844-B2
优先权日:2012-12-31
标 题:Heterocyclic compounds and methods of use thereof
发明人：FANG QUN KEVIN; CAMPBELL UNA; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

专利号:US-12234240-B2
优先权日:2018-08-09
标 题:Substituted imidazo[5,1-d][1,2,3,5]tetrazines for the treatment of cancer
发明人：HERGENROTHER PAUL J; FAN TIMOTHY M; SVEC RILEY L
权利人:UNIV ILLINOIS
摘要:New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.

专利号:CN-103848768-A
优先权日:2012-12-05
标题 :A kind of application method of carbamoyl chloride decomposition tail gas hydrogen chloride in the synthesis of cartap

专利号:CN-103848768-B
优先权日:2012-12-05
标题 :A kind of application method of carbamoyl chloride decomposition tail gas hydrogen chloride in the synthesis of cartap