CAS: 58885-58-8; Boc-ß-Ala-Ol

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156-87-6 157887-82-6 42055-15-2

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号156-87-6 3-氨基丙醇 | CAS号1140510-99-1 叔丁基2-氧代氮杂丁烷-1-羧酸 | CAS号5003-71-4 3-溴丙胺氢溴酸盐 | CAS号144-55-8 碳酸氢钠 | CAS号114326-12-4 [3-(tert-butyld... | CAS号1034098-46-8 tert-butyl 3-(t... | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号1187667-17-9 tert-butyl (3-(... | CAS号34619-03-9 碳酸二叔丁酯 | CAS号3303-84-2 B°C-beta-丙氨酸 | CAS号83948-53-2 N-B°C-3-氨基丙基溴 | CAS号98642-44-5 N-B°C-3-(甲氨基)-1-丙醇 | CAS号75178-96-0 N-叔丁氧羰基-1,3-丙二胺 | CAS号58885-60-2 (3-氧代丙基)氨基甲酸叔丁酯 | CAS号127346-48-9 N-B°C-1,3-二氨基丙烷盐酸盐 | CAS号167479-01-8 (3-碘丙基)氨基甲酸叔丁酯 | CAS号791-28-6 三苯基氧化膦 | CAS号80909-96-2 3-(叔丁氧基羰基)丙基 4-... | CAS号82409-04-9 b°C-3,3'-iminod...

📜叔丁基2-氧代氮杂丁烷-1-羧酸置于cp*rucl{(C6H5)2P-(Ch2)2Nh2-K2-P,N},Potassium Tert-Butylate,氢气体系中,用 叔丁醇 作为反应溶剂,80.0 °C,3.0 Mpa 条件下,反应 24.0H,以99%的收率获得产物n-(3-羟丙基)氨基甲酸叔丁酯
参考文献:双官能[cp * Ru(pn)]配合物催化的n-酰基氨基甲酸酯和n-酰基磺酰胺的加氢反应
标题:双官能[cp * Ru(pn)]配合物催化的n-酰基氨基甲酸酯和n-酰基磺酰胺的加氢反应
摘要:Cp 1的唤醒:双功能配合物1促进了与具有比酮,环氧化物和酰亚胺少的亲电子碳原子的底物的相互作用.该标题反应适用于将埃文斯的不对称烷基化产物还原为手性醇,以及非常好的手性恶唑烷酮助剂的回收率.ewg =吸电子基团.
DOI:10.1002/anie.200805307

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-9409945-B2
优先权日:1999-10-04
标 题 :Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
发明人：DESLONGCHAMPS PIERRE; DORY YVES; BERTHIAUME GILLES; OUELLET LUC; LAN RUOXI
权利人:OCERA THERAPEUTICS INC
摘要:A library of macrocyclic compounds of the formula (I) n n n n n n n n n n n n where part (A) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) y — bivalent radical or a covalent bond; n where part (B) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) z — bivalent radical, or a covalent bond; n where part (C) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) t — bivalent radical, or a covalent bond; and n where part (T) is a —Y-L-Z— radical wherein Y is CH 2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-9260371-B2
优先权日:2004-11-01
标题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN RUTH; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; SLETTEN ELLEN MAY
权利人:UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:WO-2022156692-A1
优先权日:2021-01-22
标 题 :Cyclic peptide viral protease inhibitor, preparation method therefor, and application thereof in antiviral drugs
发明人：LI XINGZHOU; XU LEI; LI SONG; ZHONG WU; CAO RUIYUAN; XIAO JUNHAI; ZHOU XINBO; ZHENG ZHIBING; LI WEI; FAN SHIYONG; XIAO DIAN; WANG ZIHAO; XIE FEI
权利人:ACAD OF MILITARY MEDICAL SCIENCES
摘要:The present invention relates to the field of pharmaceutical chemicals, relates to a cyclic peptide compound as shown in formula M or a stereoisomer, a tautomer or a mixture of the compound, a pharmaceutically acceptable salt, a polymorph, a eutectic or a solvate of the compound, or a stable isotope derivative, a metabolite or a prodrug of the compound, and further relates to a method and an intermediate for synthesis of the cyclic peptide compound. The provided cyclic peptide compound has a strong inhibitory effect on 3CL protease of coronavirus and 3CL protease of picornaviridae, such as Enterovirus EV71 virus. By means of cell level activity testing, the provided cyclic peptide compound has a significant inhibitory effect on EV71 virus and coronavirus. Moreover, the cyclic peptide compound as shown in formula M can generate a virus inhibition effect on a cell level by inhibiting viral protease activity, and has a good application prospect in antiviral drugs.

专利号:US-4761404-A
优先权日:1985-07-01
标题:Phospholipid analogs useful as PAF synthesis inhibitors
发明人：BUGIANESI ROBERT L; PONPIPOM MITREE M; RUPPRECHT KATHLEEN M
权利人:MERCK & CO INC
摘要:There are disclosed phospholipid analogs which are useful as PAF synthesis inhibitors. These compounds inhibit PAF (platelet-activating factor) biosynthesis and are thereby useful in the treatment of various diseases or disorders mediated by the PAF such as, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, and adult respiratory distress syndrome.