CAS: 583-06-2; 4-Oxo-4-Phenylbut-2-Enoic Acid

该化合物是一种α,β-不饱和开酮碳球酸,其结合系统能增强有机合成中的活性,其结构将苯基酮和丙烯酸酸混合物结合起来,使其成为迈克尔添加,循环和其他相加反应的多种中间体.该化合物在制药和精细化学应用中特别有用,其电子生物-碳和碳盒状组可促进选择性衍生.其晶体形式能确保处理稳定性,而同质碳基系统可进行紫外线检测,协助分析应用.该化合物因其合成灵活性和在构建复杂的分子框架方面的作用而受到重视.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号108-31-6 顺酐 | CAS号71-43-2 苯 | CAS号65245-10-5 苯甲醯乳酸 | CAS号33093-73-1 4,4-Dimethoxy-4... | CAS号19159-39-8 2,2-dimethoxy p... | CAS号95896-86-9 1,4-Cyclohexadi... | CAS号15121-89-8 反-3-苯甲酰丙烯酸乙酯 | CAS号2243-53-0 4-苯基丁-3-烯酸 | CAS号53515-22-3 3-溴-4-羰基-4-苯基丁酸 | CAS号39206-70-7 2-(4-氯苯基)-4-氧代-... | CAS号614-47-1 反-查耳酮 | CAS号2051-95-8 3-苯甲酰丙酸 | CAS号495-71-6 1,2-联苯甲酰乙烷 | CAS号282550-57-6 [6-苯基-2,2’-bi吡啶... | CAS号79-14-1 羟基乙酸 | CAS号144-62-7 草酸 | CAS号98-86-2 苯乙酮 | CAS号298-12-4 乙醛酸 | CAS号98258-72-1 甲基4-(3-羰基-3-苯基-...

合成工艺路线路线简述

    📜3-溴-4-氧代-4-苯基丁酸置于sodium Acetate,溶剂黄146体系中,化学反应生成 3-苯甲酰丙烯酸
    参考文献:Bougault,Annales De Chimie (Cachan,France),1908,Vol. <8> 15,P. 501
    标题:Bougault,Annales De Chimie (Cachan,France),1908,Vol. <8> 15,P. 501

    海关参考信息

    专利信息


    专利号:US-2024124910-A1
    优先权日:2021-02-02
    标题:Ribosome-mediated polymerization of novel chemistries
    发明人:JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO
    权利人:UNIV NORTHWESTERN; UNIV TEXAS
    摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

    专利号:US-8183016-B2
    优先权日:2009-07-03
    标题:Synthesis method of aromatic amino acids
    发明人:HWANG TZANN-SHUN; CHENG WEI-CHUN; FU HUI-CHUAN; WU SZU-PEI
    权利人:HWANG TZANN-SHUN; CHENG WEI-CHUN; FU HUI-CHUAN; WU SZU-PEI; UNIV ISHOU
    摘要:A method for synthesizing aromatic amino acids according to one aspect of the present invention includes processes of: (a) of preparing a thermostable a Thermus thermophilus aspartate aminotransferase by culturing an E. coli BL21(DE3) cell transformed with a vector comprising a gene encoding the Thermus thermophilus aspartate aminotransferase; (b) contacting the thermostable Thermus thermophilus aspartate aminotransferase of (a) with an amino donor and an amino acceptor at a temperature range of 50-80° C. to obtain an aromatic amino acid; (c) precipitating the aromatic amino acid of (b); and (d) recovering the thermostable Thermus thermophilus aspartate aminotransferase.

    专利号:EP-1278717-B1
    优先权日:2000-03-07
    标题 :One-pot synthesis of alkyl 3-cyclopropylamino-2- 2,4-dibromo-3-(difluoromethoxy)benzoyl; -2-propenoate as a useful intermediate for antibacterial quinolone medicaments

    专利号:US-11306103-B2
    优先权日:2017-11-30
    标题:Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof
    发明人:LEE JONG SEOK; SUNG DAN BI; MUN BO HYUN; LEE HYI SEUNG; LEE YEON JU; LEE JI HOON; SHIN HEE JAE; PARK SOL
    权利人:KOREA INST OCEAN SCI & TECH
    摘要:The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

    专利号:US-2011003346-A1
    优先权日:2009-07-03
    标 题 :Synthesis method of aromatic amino acids

    专利号:US-5710277-A
    优先权日:1994-09-12
    标题:Process for R (+) 1,2,3,6-tetrahydro-4-phenyl-1- (3-phenyl-3-cyclohexen-1-yl)methyl!pyridine, a central nervous system agent
    发明人:BUTLER DONALD EUGENE; GAILEY JODETTE; LE TUNG VAN; SMITH III WILLIAM JOHN; WUSTROW DAVID JUERGEN
    权利人:WARNER LAMBERT CO
    摘要:An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or alpha -chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1006/exer.2002.2012
    摘要:Taylor LM, Andrew Aquilina J, Jamie JF, Truscott RJ. UV filter instability: consequences for the human lens. Exp Eye Res. 2002 Aug;75(2):165–75. doi: 10.1006/exer.2002.2012.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知