CAS: 55912-20-4; (4-Chloro-3-Nitrophenyl)Methanol

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CAS号16588-34-4 4-氯-3-硝基苯甲醛 | CAS号96-99-1 4-氯-3-硝基苯甲酸 | CAS号16588-16-2 4-氯-3-硝基苯甲酸乙酯 | CAS号20797-48-2 4-氯-3-硝基肉桂酸 | CAS号16588-34-4 4-氯-3-硝基苯甲醛 | CAS号57403-35-7 1-氯-4-(氯甲基)-2-硝基苯 | CAS号63189-97-9 (4-amino-3-nitr...

📜4-氯-3-硝基苯甲酸置于硼烷四氢呋喃络合物,三氟化硼乙醚体系中,用 四氢呋喃 作为反应溶剂,化学反应 18.0H,以96%的收率获得产物4-氯-3-硝基苯甲醇
参考文献:使用硼烷四氢呋喃和三氟化硼醚合物方便地将高度官能化的芳香族羧酸还原为醇
标题:使用硼烷四氢呋喃和三氟化硼醚合物方便地将高度官能化的芳香族羧酸还原为醇
摘要:已经用各种金属氢化物和络合金属氢化物(例如 Liam4 及其烷氧基衍生物 Nabh,-路易斯酸)将羧酸还原为相应的醇.硼烷,以及硼烷-路易斯酸的组合:在文献中仍然没有很好地研究用硼烷络合物选择性还原高度官能化的芳族羧酸.在最近合成一种重要的神经变性抑制剂及其类似物的过程中,需要大量的关键中间体 3-羟基-4-硝基醇 (2).化合物 2 可由 3-羟基-4-Ni 还原为酸 (1) 获得.大多数已知的还原剂,例如 Lialh,,S Bh,-Thf,'B Bh,-Me2S,6 Nabh&,7 C1Co2I-Bu/nabh4 和i-Bu,Aih反应不完全(转化率为 040%).用 Bh,-Thf 和 Bf,-Ego 的组合还原化合物 1 得到完全转化和 91% 的醇 2 分离收率.彻底的在线文献搜索显示以前没有使用这种组合还原官能化芳基的例子羧酸转化为相应的苯甲醇.这鼓励我们在还原反应中进一
DOI:10.1080/00304940209355791

专利信息

专利号:US-3974110-A
优先权日:1973-10-04
标题:Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis
发明人：PATCHORNIK ABRAHAM; KALIR RAMI; FRIDKIN MATITYAHU; WARSHAVSKY ABRAHAM
权利人:YEDA RES & DEV
摘要:A process for producing reagents useful in organic synthesis, of the general formula WHEREIN Z designates the (CH2-CH-CH2-) ¦ part of a polymeric backbone of a polymer like polystyrene, a copolymer comprising polystyrene and a comonomer like divinylbenzene, butadiene, and other copolymers comprising styrene, or wherein Z designates the aliphatic moiety of a long-chain aralkyl compound having a terminal phenyl moiety; N IS AN INTEGER FROM 1 TO 8, INCLUSIVE; R designates oxygen or sulfur; X designates nitro, carbonyl, carboxyl, cyano-carbalkoxy or a carboxamido group which may be substituted on the nitrogen atom, or a halogen atom, or alkyl, unsaturated alkyl, aralkyl; RH and X together designate hydroxytriazole; which comprises reacting a compound of the general formula WHEREIN Y designates -Cl, -Br, or -OH and X and R are as defined above, with a polystyrene polymer or with a copolymer as defined above, or with a long-chain araliphatic compound as defined above, in a Friedel-Crafts reaction. According to a preferred embodiment copolymers of polystyrene and divinylbenzene are used. The invention also relates to the novel products obtained by the above reaction.

专利号:US-4215219-A
优先权日:1974-02-08
标 题 :Reagents from phenolic and 8-hydroxyquinolinic aldehyde oximes
发明人：FRIDKIN MATITYAHU; KALIR RAMI; PATCHORNIK AVRAHAM; WARSHAWSKY ABRAHAM
权利人:YEDA RES & DEV
摘要:A process for producing reagents useful in organic synthesis, for removing metal values from solutions thereof, for the capture of aldehydes, of the general formula wherein Z designates a recurring part (CH2-CH-CH2) of a polymeric backbone of a polymer like polystyrene, of a copolymer comprising polystyrene and divinylbenzene, and butadiene, or other copolymers comprising styrene moieties; or wherein Z is the aliphatic moiety of a long-chain aralkyl compound having a terminal aryl group; or wherein Z designates alkyl; corresponding compounds wherein instead of the optionally substituted phenyl group there is present an optionally substituted naphthyl group; wherein n is an integer of from 1 to 15, and wherein Q designates a group selected from: +TR wherein R designates -H, lower alkyl, aryl, which may be substituted and wherein R'' designates -H, alkyl, aryl, halogen, nitro or carboxy, or +TR wherein R is -H, lower alkyl, aryl (which may be substituted), R1 is -H, alkyl, aryl (which may be substituted), R2 is -H, alkyl, aryl or substituted aryl, and wherein Y is -H or a non-interferring substituent, which comprises chemically binding an activated chemical moiety to a group or a corresponding naphthyl-containing group, wherein Z is as defined above, according to the reaction scheme: +TR wherein Q is as defined above, or a functional group which can be converted to such group after the chemical bonding; and X is -Cl or -Br.

专利号:DE-2504397-A1
优先权日:1974-02-08
标题:POLYMERIC ORGANIC REAGENTS, IN PARTICULAR FOR ORGANIC SYNTHESIS, FOR THE SEPARATION OF METALS, FOR THE EXCHANGE OF IONS AND THE SCAPE OF ALDEHYDE AND THE PROCESS FOR THEIR PRODUCTION