专利号:US-8501954-B2 优先权日:2008-07-29 标题:Asymmetric process for making substituted 2-amino-thiazolones 发明人:CAILLE SEB; CUI SHENG; WANG XIANG; FAUL MARGARET 权利人:CAILLE SEB; CUI SHENG; WANG XIANG; FAUL MARGARET; AMGEN INC 摘要:The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts.
专利号:WO-2023023572-A1 优先权日:2021-08-19 标题:Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto 发明人:BAUM ERICH; CROUSE GARY; DEMETER DAVID; GIAMPIETRO NATALIE; Horty Lindsey; PETKUS JEFFREY; SPARKS THOMAS 权利人:CORTEVA AGRISCIENCE LLC 摘要:Provided are compounds having the structure of Formula One or Formula Two: Formula One, or Formula Two. Pesticidal compositions and their uses are disclosed. Also disclosed are methods of synthesis for compounds disclosed herein.
专利号:US-2021134398-A1 优先权日:2019-11-06 标题:Combinatorial Chemistry Computational System and Enhanced Selection Method 发明人:WISE JOHN G; VOGEL PIA D 权利人:UNIV SOUTHERN METHODIST 摘要:A method for identifying a potentially useful molecular combination includes applying a selection procedure to a compound to identify a first set of candidate molecules, the procedure including providing a chemical synthesis scheme, a virtual scaffold molecule of the compound, and a virtual reactant fragment to react with the scaffold molecule according to the scheme; preparing the reactant fragment and the scaffold molecule for analyzing combinations of them; designating a remaining scaffold subset and a remaining fragment subset if a product molecule can be formed from them; rotating the fragment subset about an axis connecting the scaffold subset and the fragment subset incrementally through 360 degrees; and identifying potentially useful combinations of the reactant fragment and the scaffold molecule; identifying a set of combinatorial fragments from the first set of candidates; and applying the selection procedure to the set of combinatorial fragments to identify a second set of candidate molecules.
专利号:US-11202774-B2 优先权日:2015-10-17 标 题 :5-substituted 2,4-thiazolidinediones (thiohydantoins), pseudothiohydantoins, and propseudothiohydantoins for use as antiviral agents 发明人:GOEL OM P 权利人:JIVA PHARMA INC 摘要:The present invention concerns the synthesis and use of formulations of 5-substituted 2, 4-thiazolidinediones, pseudothiohydantoins, and propseudothiohydantoins and 2, 4-thiazolidinediones metforminate salts for topical and systemic treatments of infections caused by herpes simplex viruses and varicella zoster viruses.
专利号:RU-2169144-C2 优先权日:1996-06-07 标题 :5-phenoxyalkyl-2,4-thiazolidinediones, methods of their synthesis, pharmaceutical composition containing thereof and intermediate compounds