📜(4-Chloro-Phenyl)-[2-(Phenyl-Hydrazono)-Eth-(E)-Ylidene]-Amine 650.0 °C,1.33 Pa 条件下,反应 1.5H,反应生成 6-氯喹喔啉 参考文献:Mcnab,Hamish,Journal Of The Chemical Society. Perkin Transactions I,1982,# 8,P. 1941-1946 标题:Mcnab,Hamish,Journal Of The Chemical Society. Perkin Transactions I,1982,# 8,P. 1941-1946
专利号:US-6472534-B2 优先权日:1999-10-21 标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors 发明人:BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K 权利人:AGOURON PHARMA 摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
专利号:US-2002038033-A1 优先权日:1999-10-21 标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
专利号:US-2003023092-A1 优先权日:1999-10-21 标题 :Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
专利号:US-6403799-B1 优先权日:1999-10-21 标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
专利号:US-5846993-A 优先权日:1992-12-22 标题:HIV protease inhibitors 发明人:DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; TATLOCK JOHN H; RODRIGUEZ MICHAEL J 权利人:AGOURON PHARMA 摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.