CAS: 5448-43-1; 6-Chloroquinoxaline

该化合物是一种杂交循环化合物,其特点是含有苯和环的双环结构,其分子式为C8H6ClN3,表明存在氯,碳,氢和氮原子.该化合物一般是黄到浅褐固体,以其在各种化学和生物应用中的作用而闻名,包括其作为药理剂的潜力. 6-克罗─克罗宁氧线展示了乙醇和二甲基硫氧化物等有机溶剂中的中等溶性,但在水中溶解度较低.五氧环的六处位置存在氯原子,影响其再活性和生物活动,使其成为医学化学领域的兴趣对象.此外,它可以参与各种化学反应,包括核本性替代物和循环,这些在合成有机化学中很有价值.

结构式图片

相似化合物

18671-97-1 62163-09-1 1932-67-8

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上下游产品

CAS号107-21-1 乙二醇 | CAS号95-83-0 4-氯邻苯二胺 | CAS号517-21-5 乙二醛亚硫酸氢钠水合物 | CAS号6935-29-1 喹喔啉1-氧化物 | CAS号151-50-8 氰化钾 | CAS号89-63-4 邻硝基对氯苯胺 | CAS号7677-24-9 三甲基氰硅烷 | CAS号2958-87-4 2,3,6-三氯喹喔啉 | CAS号6639-79-8 2,3-二羟基-6-氯喹喔啉 | CAS号39267-11-3 6-chloro-quinox... | CAS号6639-80-1 Quinoxaline, 6-... | CAS号23088-24-6 6-喹喔啉甲腈 | CAS号73855-45-5 6-氯-1,2,3,4-四氢-喹噁啉 | CAS号7467-91-6 6-羟基喹喔啉

合成工艺路线路线简述

    📜(4-Chloro-Phenyl)-[2-(Phenyl-Hydrazono)-Eth-(E)-Ylidene]-Amine 650.0 °C,1.33 Pa 条件下,反应 1.5H,反应生成 6-氯喹喔啉
    参考文献:Mcnab,Hamish,Journal Of The Chemical Society. Perkin Transactions I,1982,# 8,P. 1941-1946
    标题:Mcnab,Hamish,Journal Of The Chemical Society. Perkin Transactions I,1982,# 8,P. 1941-1946

    海关参考信息

    专利信息


    专利号:US-6472534-B2
    优先权日:1999-10-21
    标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
    发明人:BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
    权利人:AGOURON PHARMA
    摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

    专利号:US-2002038033-A1
    优先权日:1999-10-21
    标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors

    专利号:US-2003023092-A1
    优先权日:1999-10-21
    标题 :Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors

    专利号:US-6403799-B1
    优先权日:1999-10-21
    标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors

    专利号:CN-107460497-A
    优先权日:2017-07-07
    标 题 :Electrochemical catalytic synthesis of acyl-substituted electron-deficient nitrogen-containing heterocyclic compounds

    专利号:US-5846993-A
    优先权日:1992-12-22
    标题:HIV protease inhibitors
    发明人:DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; TATLOCK JOHN H; RODRIGUEZ MICHAEL J
    权利人:AGOURON PHARMA
    摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 348.
    摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 349.
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