专利号:US-11926589-B2 优先权日:2019-07-09 标 题 :Process for the synthesis of non-racemic cyclohexenes 发明人:REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND 权利人:BASF CORP; CALIFORNIA INST OF TECHN 摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.
专利号:US-8119794-B2 优先权日:2009-03-31 标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid 发明人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD 权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB 摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.
专利号:US-8101747-B2 优先权日:2009-03-31 标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid 发明人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD 权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB 摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.
专利号:US-10294336-B2 优先权日:2014-11-27 标题 :Synthesis of polymer polyols in unsaturated polyols, polymer polyols and their use 发明人:KOENIG CHRISTIAN; EMGE ANDREAS; OTERO MARTINEZ IRAN 权利人:BASF SE 摘要:The present invention relates to the synthesis of polymer polyols in unsaturated polyols as liquid phase, polymer polyols and their use.
专利号:WO-2017030685-A1 优先权日:2015-08-14 标题 :One-pot synthesis of anhydropentitol mono- and diethers 发明人:STENSRUD KENNETH 权利人:ARCHER DANIELS MIDLAND CO 摘要:A process for preparing anhydropentitol mono- and diethers from C 5 sugar alcohols is described. The process involves performing in a single reaction vessel consolidated reactions that a) cyclize dehydratively a linear C 5 sugar alcohol and b) etherify a resulting anhydropentitol. Each of the reactions is catalyzed by a very low amount of a water-tolerant Lewis acid catalyst relative to the starting sugar-alcohol. Depending on the reaction conditions, the synthesis method is efficient, selective and affords good yields of mono- and diethers. The anhydropentiol ethers can serve as renewable substitute precursors of petroleum incumbents for use in the making of surfactants and plasticizers.
专利号:WO-2017100402-A1 优先权日:2015-12-11 标 题 :One-pot synthesis of anhydropentitol esters from pentitols, catalyzed by water-tolerant lewis acids 发明人:STENSRUD KENNETH 权利人:ARCHER DANIELS MIDLAND CO 摘要:A procedure for preparing anhydropentitol mono, di, and tri esters is described. The process is performed in a single vessel and involves sequential dehydrative cyclization and carboxylic acid acylation steps. Each step is catalyzed by low loadings of a water-tolerant Lewis acid catalyst. The method of synthesis is efficacious and depending on the reaction condition, generates modest to high yields of the target mono-, di-, and triesters. The esters can be practical surrogates of incumbent petroleum materials of similar structure used for surfactants and plasticizers.
摘要:Dissanayake, P.; Averill, D. J.; Allen, M. J., Science of Synthesis Knowledge Updates, (2011) 4, 7. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 293. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 269. 摘要:Kobayashi, S., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 1. 摘要:Ayaz, M.; De Moliner, F.; Morales, G. A.; Hulme, C., Science of Synthesis: Multicomponent Reactions, (2013) 1, 103.