CAS: 49755-94-4; 2-Amino-N-Methylacetamide Hydrochloride

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📜2-氯-N-甲基乙酰胺置于氨体系中,用 甲醇 作为反应溶剂,化学反应 24.0H,反应生成 H-甘氨酸-Nhme盐酸盐
参考文献:The Structure-Activity Profile Of Mercaptobenzamides' Anti-Hiv Activity Suggests That Thermodynamics Of Metabolism Is More Important Than Binding Affinity To The Target
标题:The Structure-Activity Profile Of Mercaptobenzamides' Anti-Hiv Activity Suggests That Thermodynamics Of Metabolism Is More Important Than Binding Affinity To The Target
摘要:Mercaptobenzamide Thioesters And Thioethers Are Chemically Simple Hiv-1 Maturation Inhibitors With A Unique Mechanism Of Action,Low Toxicity,And A High Barrier To Viral Resistance. A Structure-Activity Relationship (Sar) Profile Based On 39 Mercaptobenzamide Prodrug Analogs Exposed Divergent Activity/toxicity Roles For The Internal And Terminal Amides. To Probe The Relationship Between Antiviral Activity And Toxicity,We Generated An Improved Computational Model For The Binding Of Mercaptobenzamide Thioesters (Samts) To The Hiv-1 Ncp7 C-Terminal Zinc Finger,Revealing The Presence Of A Second Low-Energy Binding Orientation,Hitherto Undisclosed. Finally,Using NMR-Derived Thiol-Thioester Exchange Equilibrium Constants,We Propose That Thermodynamics Plays A Role In Determining The Antiviral Activity Observed In The Sar Profile. (C) 2019 Published By Elsevier Masson Sas.
DOI:10.1016/j.Ejmech.2019.06.020

专利信息

专利号:US-2009215986-A1
优先权日:2006-03-08
标题:Solution Synthesis of Peptide Cell Growth Stimulators
发明人：EPSTEIN DAVID; KRUSZYNSKI MARIAN F; MARSH CHRISTOPHER; SCHMIDT ALBERT
权利人:EPSTEIN DAVID; KRUSZYNSKI MARIAN F; MARSH CHRISTOPHER; SCHMIDT ALBERT
摘要:A solution phase synthetic method for preparing basic tripeptides of the formula Gly-Xaa-Gly-X which have in various biological properties such as stimulating protein production when used as additives in a bioreactor. The basic tripeptides of the invention may be produced on gram or kilogram scale.

专利号:US-2007213505-A1
优先权日:2006-03-08
标 题 :Solution Synthesis of Peptide Cell Growth Stimulators