CAS: 3410-66-0; (R)-Methyl 2-Amino-3-(4-Hydroxyphenyl)Propanoate

上下游产品

methanol L-tyrosine 3-(4-Hydroxy-phenyl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester 3-(4-Hydroxy-phenyl)-2-((E)-2-methyl-3-oxo-propenylamino)-propionic acid methyl esterN-stearoyl-DL-tyrosine methyl esterN-stearoyl-DL-tyrosine methyl ester 2-diazo-3-(4-hydroxyphenyl)propanoic acid methyl ester methyl trityltyrosinate 3-(4-Hydroxy-phenyl)-2-[2-(1H-indol-3-yl)-2-oxo-acetylamino]-propionic acid methyl ester

📜丁氧羰基-D-酪氨酸-甲氧基酯置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,反应生成 D-酪氨酸甲酯
参考文献:在地面和激发态的酪氨酸/二苯甲酮二联体中的头尾相互作用:NMR和激光闪光光解研究.
标题:在地面和激发态的酪氨酸/二苯甲酮二联体中的头尾相互作用:NMR和激光闪光光解研究.
摘要:在新合成的二苯甲酮/酪氨酸二元组(bp逻辑和tyr)中,头到尾接触的形成分别通过NMR技术和激光闪光光解法以基态和激发三重态进行探测.三重态激发的酮对苯酚的高亲和力被用来追踪在激发态下对高反应性的几何要求.随着溶剂氢键接受能力的提高,对速率的阻滞作用与苯酚的基态掩蔽有关.在给定的溶剂中,分子内氢原子转移反应的效率很大程度上取决于连接基的性质:三重态分子内淬灭的速率常数覆盖10(5)至10(8)s(-1).观测到的反应顺序与a)紧密接触的可能性(来自分子动力学模拟)和b)供体和受体部分的pi系统之间电子重叠的程度(来自NMR)相关.在9种不同溶剂中对NMR光谱进行的广泛调查显示,Bp逻辑和tyr Dyads的芳族部分之间的头尾相互作用已经处于基态.基态的有利的芳族-芳族相互作用似乎对应于高的激发态反应性.在9种不同溶剂中对NMR光谱进行的广泛调查显示,Bp逻辑和tyr Dyads的芳族部分
DOI:10.1002/chem.200800315

专利信息

专利号:US-6140529-A
优先权日:1998-10-22
标 题 :Synthesis of optically active cyclohexylphenylglycolate esters
发明人：BAKALE ROGER P; LOPEZ JORGE L; MCCONVILLE FRANCIS X; VANDENBOSSCHE CHARLES P; SENANAYAKE CHRIS HUGH
权利人:SEPRACOR INC
摘要:A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.

专利号:US-11530204-B2
优先权日:2019-09-30
标 题 :Biocatalytic synthesis of cryptophycin anticancer agents
发明人：SHERMAN DAVID H; SCHMIDT JENNIFER J
权利人:UNIV MICHIGAN REGENTS
摘要:The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.

专利号:WO-2021067460-A1
优先权日:2019-09-30
标题 :Biocatalytic synthesis of cryptophycin anticancer agents

专利号:WO-0023414-A2
优先权日:1998-10-22
标题:Synthesis of optically active cyclohexylphenylglycolic acid and its esters

专利号:AU-2003271292-A2
优先权日:1998-10-22
标 题 :Synthesis of optically active cyclohexylphenylglycolic acid and its esters

专利号:AU-2003271292-A1
优先权日:1998-10-22
标题:Synthesis of optically active cyclohexylphenylglycolic acid and its esters