CAS: 23743-26-2; 1,2-Bis(Dicyclohexylphosphino)Ethane

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CAS号106-93-4 1,2-二溴乙烷 | CAS号829-84-5 二环己基磷 | CAS号16527-12-1 ethane-1,2-diyl... | CAS号107-06-2 1,2-二氯乙烷 | CAS号96165-44-5 [1,2-双(二环己基)乙烷钯...

📜1,2-Bis(Dicyclohexylphosphinyl)Ethane置于三氯硅烷体系中,用 Xylene 用作溶剂,化学反应 18.0H,以81%的收率获得1,2-双(二环己基磷基)-乙烷
参考文献:通过michaelis-arbuzov型重排合成1,2-双[(二有机)膦基]乙烷
标题:通过michaelis-arbuzov型重排合成1,2-双[(二有机)膦基]乙烷
摘要:研究了三步合成二(二有机膦基)乙烷r 2 Pch 2 Ch 2 Pr 2的方法,其中r = Et,Ph,I Pr,Cy和t Bu.第一步,在室温下于thf溶液中,在三乙胺存在下,使二有机氯膦与乙二醇反应.对于r = Ph,I Pr和cy,以高收率获得双亚膦酸酯r 2 Poch 2 Ch 2 Opr 2.对于r = Et,无法分离出次亚膦酸酯,但可能与80%的四乙基二膦醚et 2 Ppet 2形成混合物,作为次要组成部分.二反应吨-Butylchlorophosphine与乙二醇发生在温度大于130°C,使二-吨-丁基氧化膦,吨卜2 Ph(o),作为唯一的含磷产物.双亚膦酸酯r 2 Poch 2 Ch 2 Opr 2(r = Ph,I Pr和cy)在190-260oc下热解24 H,得到双膦氧化物r 2 P(o)ch 2 Ch 2(o)pr 2在9%(ph),90%(我pr)和93%(cy)的收率.Dsc研究cy
Doi:10.1016/s0022-328X(01)01431-0

专利信息

专利号:US-11427530-B2
优先权日:2018-02-09
标 题 :Synthesis of 4-chlorokynurenines and intermediates
发明人：LEVIN DANIEL; LEEMING PETER; EISENREICH EMERICH; LIU XUEJUN KARL
权利人:VISTAGEN THERAPEUTICS INC
摘要:The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-RE41366-E
优先权日:2001-06-15
标 题 :Total synthesis of galanthamine, analogues and derivatives thereof
发明人：THAL CLAUDE; GUILLOU CATHERINE; BEUNARD JEAN-LUC; GRAS EMMANUEL; POTIER PIERRE
权利人:CT NAT DEL LA RECH SCIENT CNRS
摘要:The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R 1 =a hydrogen atom, R 2 =a hydroxy group, R 1 and R 2 together form â•?O, R 3 , R 4 , and R 5 independently=a hydrogen atom, a hydroxy group or a (C 1 -C 2 )alkoxy group, R 6 â•?H, (C 1 -C 12 )alkyl, (CH 2 ) n NR 7 R 8 , or —(CH 2 ) n N + R 7 R 8 R 9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO 2 , or —NR 6 group where R 6 is as defined above or is an amine protecting group.

专利号:US-11407993-B2
优先权日:2017-02-14
标 题 :Method for the synthesis of DNA conjugates by micellar catalysis
发明人：BHAT AVINASH SHASHIDHAR; KLIKA SKOPIC MATEJA; BRUNSCHWEIGER ANDREAS; WEBERSKIRCH RALF
权利人:UNIV DORTMUND TECH
摘要:A method for the synthesis of a chimeric conjugate molecule by micellar catalysis that may form part of DNA-encoded compound libraries. A DNA-coupled organic starter molecule may be reacted with another organic compound, using a catalyst located within a micelle, to form a conjugate of an organic candidate compound coupled to a DNA identifier tag.

专利号:US-7538061-B2
优先权日:2001-05-18
标题 :One-step production of 1,3-propanediol from ethylene oxide and syngas with a cobalt-iron catalyst
发明人：KNIFTON JOHN FREDERICK; JAMES TALMADGE GAIL; SLAUGH LYNN HENRY; WEIDER PAUL RICHARD; ALLEN KEVIN DALE; POWELL JOSEPH BROUN
权利人:SHELL OIL CO
摘要:Disclosed is a new catalyst composition comprising a bimetallic Co—Fe catalyst, optionally complexed with a ligand selected from a N-heterocycle, phosphine, or porphorine ligand, that provides a lower cost alternative for the one step synthesis of 1,3-propanediol (1,3-PDO) from ethylene oxide and synthesis gas. For example, a catalyst containing cobalt carbonyl: iron carbonyl with no ligand, or a catalyst containing a cobalt carbonyl: octaethylporphine iron acetate provide moderate yields of 1,3-PDO in a one step synthesis under mild conditions.

专利号:US-2025002518-A1
优先权日:2023-06-16
标 题 :Synthesis of heteroarynes and use thereof
发明人：MATTMILLER ROBERTS COURTNEY COLLEEN; HUMKE JENNA NICOLE; QUINLIVAN ANSEL ANNABEL; BELLI ROMAN GIANCARLO; KARGBO SALLU SO; PLASEK ERIN ELIZABETH
权利人:UNIV MINNESOTA
摘要:Disclosed herein are heterocyclic arynes and methods for preparing the same. Heteroarynes such as 5-membered O- or N-heterocyclic arynes have been considered inaccessible due to ring strain associated with the triple bond. The methods described herein demonstrate that these arynes can be successfully prepared through the utility of pi-backbonding from a transition metal. Synthetic utility of this method has been demonstrated by the facile synthesis and functionalization of heterocycles using these heteroaryne building blocks.