CAS: 198480-21-6; 1-(4-(2-(Azepan-1-yl)Ethoxy)Benzyl)-5-(Benzyloxy)-2-(4-(Benzyloxy)Phenyl)-3-Methyl-1H-Indole

上下游产品

CAS号223251-25-0 1-(2-(4-(氯甲基)苯氧... | CAS号198479-63-9 3-甲基-5-苄氧基-2-(4... | CAS号1343413-18-2 5-benzyloxy-2-(... | CAS号111-49-9 环己亚胺 | CAS号1343413-12-6 2-(4-{[5-(benzy... | CAS号623-05-2 对羟基苯甲醇 | CAS号35081-45-9 1-[4-(苄氧基)苯基]-2... | CAS号51388-20-6 4-苄氧基苯胺盐酸盐 | CAS号198481-32-2 1-[[4-[2-(氮杂环庚烷...

对羟基苯甲醇置于lithium Aluminium Tetrahydride,Sodium Hydride,Potassium Carbonate体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应生成5-苄氧基-2-(4-苄氧基-苯基)-3-甲基-1-[4-(2-氮杂环庚烷-1-基-乙氧基)-苄基]-1H-吲哚
参考文献: Use Of Pipendoxifene To Treat Sars-Cov-2 Infection[fr] Utilisation De Pipendoxifène Pour Traiter Une Infection Par Sars-Cov-2
标题: Use Of Pipendoxifene To Treat Sars-Cov-2 Infection[fr] Utilisation De Pipendoxifène Pour Traiter Une Infection Par Sars-Cov-2
摘要:Methods And Compositions For Treating Rna Viral Infections,Including Behavior Symptoms Of The Rna Viral Infections,Are Disclosed Herein. Also Disclosed Are Methods And Compositions For Reducing The Progression Of Clinical Complications Associated With Rna Viral Infections. The Methods,For Example,Can Include Administering Pharmaceutical Compositions Comprising Pipendoxifene Or Analogues Thereof (E.G.,A Compound Of Formula (I),Formula (II),Or Formula (III)) To A Patient In Need. One Or More Additional Therapeutic Agents Can Also Be Administered To The Patient In The Disclosed Methods.

专利信息

专利号:US-2012253038-A1
优先权日:2009-04-13
标 题:Processes for the synthesis of bazedoxifene acetate and intermediates thereof
发明人：JOSHI SHREERANG; BHUTA SACHIN; TALUKDAR SANJAY; SAWANT SUDHIR; VENKATRAMAN DEEPAK
权利人:JOSHI SHREERANG; BHUTA SACHIN; TALUKDAR SANJAY; SAWANT SUDHIR; VENKATRAMAN DEEPAK; SANDOZ AG
摘要:Efficient processes for the synthesis of pharmaceutically useful compounds such as (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate (Formula IX) using cyanomethoxybenzyl halides of Formula III, where X=Halogens e.g., Cl, F, Br, I; G=Any electron donating or electron withdrawing substituent.

专利号:WO-2013001511-A1
优先权日:2011-06-30
标题 :Novel salt intermediates for the synthesis of bazedoxifene acetate and process thereof
发明人：LUTHRA PARVEN KUMAR; BHUTA SACHIN; NAIR RAJI; SALUNKE SANJUKUMAR; VENKATARAMAN DEEPAK
权利人:SANDOZ AG; LUTHRA PARVEN KUMAR; BHUTA SACHIN; NAIR RAJI; SALUNKE SANJUKUMAR; VENKATARAMAN DEEPAK
摘要:The present invention relates to novel salts of 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-H-indole which are useful intermediates in the production of (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1-H- indol-5-ol acetic acid commonly known as bazedoxifene acetate and related compounds.

专利号:US-10844047-B2
优先权日:2018-06-21
标题:Process for the preparation of bazedoxifene
发明人：FERRARI MASSIMO; ZANI DANIELE DE; VEZZOSI STEFANO; BELOTTI PAOLO
权利人:ERREGIERRE SPA
摘要:The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.

专利号:JP-2012523445-A
优先权日:2009-04-13
标 题 :Method for the synthesis of bazedoxifene acetate and its intermediates

专利号:WO-2010118997-A1
优先权日:2009-04-13
标 题 :Processes for the synthesis of bazedoxifene acetate and intermediates thereof

专利号:EP-2419406-A1
优先权日:2009-04-13
标题 :Processes for the synthesis of bazedoxifene acetate and intermediates thereof