CAS: 17202-49-2; 4-Azidosulfonylbenzoic Acid

该化合物是一种有机化合物,其特征是附于苯并酸结构的Azido组(-N3)和磺酰(-SO2),该化合物一般是固体,以其在有机合成和材料科学中的潜在应用而著称,特别是在开发功能化聚合物和点击化学中作为构件.Azido组因其反应活跃性而引人注目,允许各种组合反应,而Sursyl组则在不同溶剂中增强化合物的溶性性和稳定性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号5399-63-3 4-磺基苯甲酸单钾盐 | CAS号10130-89-9 4-氯磺酰基苯甲酸 | CAS号103324-91-0 4-(acetylsulfam... | CAS号138-41-0 卡西尼特

合成工艺路线路线简述

    📜Potassium P-Carboxybenzenesulfonate置于氯磺酸,Sodium Azide体系中,用 水,丙酮 用作溶剂,化学反应 5.5H,以52%的收率获得4-羧基苯磺叠氮
    参考文献:3-酰基氨基氮杂环酮向顺式-3,4-二取代氮杂环丁酮的生成,电环开环和前所未有的转化
    标题:3-酰基氨基氮杂环酮向顺式-3,4-二取代氮杂环丁酮的生成,电环开环和前所未有的转化
    摘要:尝试通过将适当功能化的铑卡宾插入 β-内酰胺 NH 键来合成头孢克洛的核,从而导致对硫的攻击,然后碎裂成四元硫杂环酮和四元 3-酰基氨基氮杂环酮. 氮杂环丁酮经过电环开环,在 40oc 下的计算半衰期为 11 秒,生成反式二取代的异氰酸乙烯酯,但可以被饱和,不饱和的烯丙醇和苄醇捕获,形成 3,4-二取代的氮杂环丁酮.其中顺式异构体占优势.关键词:卡宾铑,转矩化学,氮杂环丁酮,巯基氮杂环丁酮.
    Doi:10.1139/v01-102

    海关参考信息

    专利信息


    专利号:US-4287123-A
    优先权日:1980-01-14
    标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
    发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
    权利人:MERCK & CO INC
    摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

    专利号:US-4282148-A
    优先权日:1980-01-14
    标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
    发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
    权利人:MERCK & CO INC
    摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

    专利号:US-4414155-A
    优先权日:1980-01-14
    标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
    发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
    权利人:MERCK & CO INC
    摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

    专利号:US-4269772-A
    优先权日:1980-01-14
    标 题 :Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
    发明人：MELILLO DAVID G; RYAN KENNETH M
    权利人:MERCK & CO INC
    摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R5 and R6 are removable protecting groups.

    专利号:WO-2023039068-A1
    优先权日:2021-09-08
    标题:Compositions and methods for synthesis of peptide nucleic acid intermediates
    发明人：COULL JAMES M; GILDEA BRIAN D
    权利人:NEUBASE THERAPEUTICS INC
    摘要:The present disclosure provides intermediates for the synthesis of peptide nucleic acid (PNA) backbones and monomers, such as cyclic intermediates, and methods of making the same.

    专利号:US-4349687-A
    优先权日:1980-01-14
    标 题:Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
    发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
    权利人:MERCK & CO INC
    摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin via intermediates II and IIa: II IIa wherein R is a readily removable carboxyl protecting group.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Heydt, H., Science of Synthesis, (2004) 27, 844.
    摘要:Shcherbakova, I., Science of Synthesis, (2007) 31, 815.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知