CAS: 171364-80-0; Methyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Benzoate

相似化合物

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上下游产品

CAS号619-42-1 对溴苯甲酸甲酯 | CAS号73183-34-3 双戊酰二硼 | CAS号1126-46-1 甲基-4-氯苯甲酸甲酯 | CAS号17763-67-6 三氟甲烷磺酰苯 | CAS号17763-71-2 methyl 4-[(trif... | CAS号619-44-3 4-碘苯甲酸甲酯 | CAS号25015-63-8 频那醇硼烷 | CAS号17640-15-2 氰基甲酸甲酯 | CAS号106-37-6 对二溴苯 | CAS号61676-62-8 2-异丙氧基-4,4,5,5-... | CAS号473596-87-1 2-甲基-4-甲酸甲酯苯硼酸频那醇酯 | CAS号223127-51-3 methyl 4-(5-nit... | CAS号20442-96-0 Methyl 4-azidob... | CAS号222986-49-4 4-(6-氨基吡啶-3-基)苯甲酸甲酯 | CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号276694-16-7 4-(肼羰基)苯基硼酸频哪醇酯 | CAS号223127-49-9 4-(5-硝基吡啶-2-基)苯甲酸 | CAS号1129-35-7 对氰基苯甲酸甲酯 | CAS号22821-70-1 4-甲磺酰基苯甲酸甲酯

4-丁酰基苯甲酸甲酯置于吡啶,盐酸羟胺,Sodium Acetate,Potassium Carbonate,2-(4,5-二氢-4,4-二甲基-2-恶唑基)吡啶,四(3,5-二(三氟甲基)苯基)硼酸钠,三[3,4-双(三氟甲基)苯基]膦,Palladium Dichloride体系中,用 乙醇,二氯甲烷,1,2-二氯乙烷 用作溶剂,化学反应 12.0H,反应生成4-甲氧甲酰苯硼酸频哪醇酯
参考文献:通过配体促进的cc键活化来转化芳基酮.
标题:通过配体促进的cc键活化来转化芳基酮.
摘要:芳族亲电试剂(芳基卤化物,芳基醚,芳基酸,芳基腈等)与亲核试剂的偶联是合成芳基化合物的核心方法.由于芳基酮的丰度,通过碳-碳键活化以类似方式进行芳基酮的转化可大大扩展合成芳基化合物的工具箱.这种方法的探索性研究通常基于环应变释放和螯合辅助引发的碳-碳裂解,并且产物也仅限于特定的结构基序.在这里,我们报告了一种配体促进β-碳消除的策略,以激活碳-碳键,这导致芳基酮发生一系列转化,从而生成有用的芳基硼酸酯,以及联芳基,芳基腈和芳基烯烃.吡啶-恶唑啉配体的使用对于这种催化转化至关重要.据报道,通过简单的一锅操作,芳基酮的克级硼酸酯化反应.该策略的潜在效用还通过丙磺舒,阿达帕林和脱氧雌酮,芬芳类香囊素和载脂蛋白的天然产物的晚期药物分子多样化而得到证明.
Doi:10.1002/anie.202006740

专利信息

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.

专利号:US-11359049-B2
优先权日:2017-09-21
标题:Gold catalyzed polymerization reactions of unsaturated substrates
发明人：AZOULAY JASON D; TROPP JOSHUA; KING ERIC
权利人:AZOULAY JASON D; TROPP JOSHUA; KING ERIC; THE UNIV OF SOUTHERN MISSISSIPPI
摘要:The present invention provides novel methods and processes for polymerizing unsaturated substrates, such as alkyne bearing monomers, with arenes. The polymerizations are catalyzed by gold (Au) catalysts/complexes and/or other cocatalysts. The invention further provides novel structurally complex polymers prepared in high yield via an intermolecular polyhydroarylation mechanism. Such resulting products comprise oligomeric and polymeric materials with novel molecular architectures and microstructures, which subsequently impart unique properties. The invention includes both the synthesis methods and processes and the resulting compounds and compositions of matter.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).