CAS: 122745-09-9; (R)-2-Amino-3-(Naphthalen-1-yl)Propanoic Acid Hydrochloride

相似化合物

78306-92-0 138774-93-3 55447-00-2

📜(Z)-2-Benzamido-3-(Naphthalen-1-yl)Acrylic Acid置于盐酸,(-)-(R)-Cationic Rhodium Complex Of "Propharos",氢气体系中,用 甲醇 用作溶剂,25.0 °C,100.0 Kpa 条件下,反应 7.0H,反应生成3-(1-萘基)-D-丙氨酸盐酸盐
参考文献:Unusual Amino Acids Iii. Asymmetric Synthesis Of 3-Arylalanines
标题:Unusual Amino Acids Iii. Asymmetric Synthesis Of 3-Arylalanines
摘要:21 (Z)-Alpha-N-Benzoylamino-Beta-Arylacrylic Acids And Their Esters Were Prepared By Known Procedures And Hydrogenated To The Corresponding Optically Active Alpha-Benzoyl-Beta-Arylalanine Derivatives With Optical Yields In The Range Of 82-95% Ee Using The Cationic Rhodium Complex Of ''Propraphos'' As The Chiral Catalyst No Electronical Influences Of The Substituents At The Aryl Moiety On The Enantioselectivity Were Observed But A Sterical One,Proved By X-Ray Crystallographic Analysis And Computer-Aided Modellings. Deacylation Of The Hydrogenated Spezies Produced The Hydrochlorides Of The 3-Arylalanines Attended By A Partial Racemisation In This Case The Hydrogenation Of Urethane Type Protected Dehydroaminoacid Derivatives Seems To Be The Alternative.
Doi:10.1016/s0957-4166(00)86017-6